Literature Review

All posts tagged with “Clinical News | Pharmacy & Medication News | Pain Management News.”



Assisted ventilation withdrawal in motor neuron disease: updated results

03/26/25 at 03:00 AM

Assisted ventilation withdrawal in motor neuron disease: updated results BMJ Supportive & Palliative Care; by Lucy Bleazard, Jonathan Palmer, David Wenzel, Thomas Jeffery, and Christina Faull; 3/24/25 Introduction: Patients with ventilator-dependent motor neuron disease (MND) may request withdrawal of their assisted ventilation. Facilitating this process as a healthcare professional (HCP) can be emotionally and practically challenging. The Association for Palliative Medicine (APM) issued guidance to support HCPs and invited anonymised accounts of the withdrawal process to provide an update on the guidance. ... Results: Younger patients tended to need higher doses to achieve adequate symptom management prior to withdrawal. Practices of weaning the ventilator varied significantly between respondents. The median time to death following withdrawal of ventilation was 30 min, with three-quarters of patients dying within 2 hours. Conclusion: This is the largest data set to date regarding the withdrawal of assisted ventilation in MND. This updated analysis reaffirms that a personalised, titrated approach remains appropriate and effective. The revised APM Guidance 2025 incorporates new sections on recommendations for managing the ventilator. [Continue reading ...]

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Harmonizing federal and Florida laws on prescribing controlled substances through telehealth

03/26/25 at 03:00 AM

Harmonizing federal and Florida laws on prescribing controlled substances through telehealth JD Supra; by Jeremy Burnette, Martin Dix, and John Hood; 3/24/25 Practitioners who want to prescribe controlled substances via telehealth to patients in Florida must meet the requirements of both federal and state law. The federal Drug Enforcement Administration (DEA) and the Florida legislature have recently amended the applicable federal regulations and state laws, respectively, to allow the prescribing of controlled substances via telehealth[*] without conducting an in-person evaluation under certain circumstances. There are key differences between federal and state law, so practitioners prescribing controlled substances via telehealth to patients in Florida should be aware of the particular requirements of each. [Continue reading ...]

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RFK Jr. continues Opioid Crisis PHE into its eighth year

03/21/25 at 03:00 AM

RFK Jr. continues pioid Crisis PHE into its eighth year Inside Health Policy; by Dorothy Mills-Gregg; 3/19/25 HHS Secretary Robert F. Kennedy Jr. recently renewed the department’s longest ongoing public health emergency (PHE) first declared under the first Trump administration: the opioid abuse crisis. While the Centers for Disease Control and Prevention found a 25.5% decrease in overdose deaths in 2024 compared to the previous year, HHS says the opioid PHE needs to be renewed for another 90 days so federal coordination efforts can continue and key flexibilities for HHS will be preserved.Editor's note: How recently have you reviewed your Policies & Procedures for destroying drugs in the patient's home, upon death--in accordance with state laws? For staff education and accountability? For communicating this with family? For assessing possible drug diversion of opioids, with appropriate follow-up actions? Additionally, numerous hospice bereavement programs have been flooded with grief needs of bereaved family members from opioid deaths. Click here for the U.S. Department of Justice's Drug Enforcement Administration - Diversion Control Divsion; more focused, scroll down to their "Home Disposal Methods."

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Hospice community responds to proposed DEA telehealth prescribing rule

03/21/25 at 02:00 AM

Hospice community responds to proposed DEA telehealth prescribing rule Hospice News; by Jim Parker; 3/20/25 A proposed rule by the U.S. Drug Enforcement Administration (DEA) could impede timely access to medications for hospice and palliative care patients, according to members of the hospice community. ... If finalized, this proposed rule would require prescribers to register with the DEA before they are allowed to prescribe schedule II-V controlled substances, along with some monitoring and other requirements.  ... Implementation of the proposed rule would have adverse consequences for hospice and palliative care patients, according to the National Alliance for Care at Home. ... The Alliance made several recommendations to the DEA regarding the proposal: 

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Psychedelics for cancer pain and associated psychological distress: A narrative review of a potential strategy

03/15/25 at 03:20 AM

Psychedelics for cancer pain and associated psychological distress: A narrative review of a potential strategyCancer Medicine; Erika Belitzky, Lis Victoria Ravani Carvalho, Melissa Taylor, Cristina Naranjo Ortiz, Laura Baum, David A Fiellin, Maryam B Lustberg; 3/25Cancer pain can ... be exacerbated by anxiety, depression, quality of life challenges, and fear of death and dying, as well as by fear of recurrence or progression. Psychedelics, such as lysergic acid diethylamide (LSD), psilocybin, mescaline, and N,N-dimethyltryptamine (DMT), are under consideration as new pharmacologic strategies for mitigating pain and the distress associated with cancer pain and associated symptom burden. Although published studies are limited, regulatory hurdles have decreased. Many clinical trials are underway to assess further the use of psychedelics and behavioral counseling for patients with cancer and comorbidities such as anxiety or depression. Early results are promising, and additional research is needed to understand efficacy and tolerability in broader cancer populations. 

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Hallucinogens may elevate death risk by more than twofold

03/11/25 at 03:00 AM

Hallucinogens may elevate death risk by more than twofold Medscape; by Liz Scherer; 3/5/25 Hallucinogens are associated with a 2.6-fold increased risk for premature death in some individuals seeking emergency care, according to a recent study. The risks are especially substantial in vulnerable patients who are suicidal, who are susceptible to severe mental illness, or have comorbid conditions such as respiratory disease or cancer. The findings come at a time of renewed interest in the therapeutic potential of substances like psilocybin, lysergic acid diethylamide, methylenedioxymethamphetamine (MDMA), and ketamine for mood and substance use disorders. In 2023, the Canadian Institutes of Health Research allocated roughly $3 million to three clinical trials examining psilocybin-assisted psychotherapy in the treatment of alcohol use disorder, treatment-resistant depression, and end-of-life psychological distress in patients with advanced cancer.

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Daughter indicted for killing mother with morphine in Evans

02/26/25 at 03:00 AM

Daughter indicted for killing mother with morphine in Evans The Augusta Press, Augusta, GA; by Greg Rickabaugh; 2/25/25The daughter of a woman who died in an Evans assisted living home from a fatal dose of morphine has been indicted for malice murder. Rachel Elaine Waters, 41, is expected to surrender this week on murder charges in the death of 74-year-old Marsha Sprayberry Foster, according to Columbia County authorities.An indictment says that Waters administered a lethal dose of morphine on July 12, 2023, while her mother was at the Marshall Pines assisted living on North Belair Road. The cause of death was determined in an autopsy, showing that excessive use of the unprescribed morphine was the reason for her death. Foster had Alzheimer’s disease, and the morphine was reportedly left behind by hospice workers and used by the daughter without authorization.

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Center for Hospice Care's BreatheEazy Program supports patients with respiratory issues

02/18/25 at 03:00 AM

Center for Hospice Care's BreatheEazy Program supports patients with respiratory issues LaporteCounty.Life; by Garrett Spoor; 2/13/25 One of the toughest health challenges a person can face is the trouble of breathing. Center for Hospice Care comes across a lot of patients who experience this issue and encourages many of them to become a part of their BreatheEazy program. Dr. Karissa Misner, medical director at Center for Hospice Care, considers the BreatheEazy program to be a monumental boost for patients who might have respiratory issues. “This is a specialized pulmonary program for our patients with chronic obstructive pulmonary disease,” Misner said. “It can also be used for many other terminal diagnoses that affect the lungs. Whenever there is any type of illness that causes difficulty in breathing, we can utilize this program.”

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Kroger partners with Express Scripts to expand pharmacy services

02/10/25 at 03:00 AM

Kroger partners with Express Scripts to expand pharmacy services Becker's Hospital Review; by Alexandra Murphy; 2/6/25 Cincinnati-based Kroger Health has reached a new agreement with Express Scripts, the pharmacy benefit services arm of Evernorth, to provide access to prescription medications and health services at the Kroger Family of Pharmacies for Express Scripts Customers. Under the new agreement, the Kroger Family of Pharmacies will resume serving customers in Express Scripts' Medicare Part D and Tricare/Department of Defense plans, according to a Feb. 5 Kroger news release. This comes after Kroger ended its contract with Express Scripts in September of 2022, after months of unsuccessful negotiations over a new agreement. 

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Grant renews funding for pain and aging center

01/31/25 at 03:00 AM

Grant renews funding for pain and aging center Cornell Chronicle; by Weill Cornell Medicine; 1/30/25 The Translational Research Institute for Pain in Later Life (TRIPLL), a New York City-based center to help older adults prevent and manage pain, has been awarded a five-year, $5 million renewal grant from the National Institute on Aging (NIA). ... The institute seeks to apply insights from psychology, sociology, economics and communications to develop and implement effective pain management techniques that are acceptable to and practical for older adults.

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Opioid painkillers less available to people of color

01/31/25 at 03:00 AM

Opioid painkillers less available to people of color HealthDay News / Coastal Breeze News, Marco Island, FL; 1/30/25 People of color now have less access to prescription opioid painkillers than white patients, an unintended consequence of efforts to stem America’s opioid epidemic. Communities of color have a 40% to 45% lower distribution of commonly prescribed opioids, compared to majority white communities, researchers reported in a study published Jan. 23 in the journal Pain. This could prevent opioid painkillers from reaching those in true need of them, like cancer patients, researchers said. 

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DEA proposed telemedicine prescribing rule could burden hospice physicians and hospice operations

01/29/25 at 03:00 AM

DEA proposed telemedicine prescribing rule could burden hospice physicians and hospice operations Morgan Lewis, Washington, DC; by Howard J. Young, Jacob J. Harper, and Roshni Edalur; 1/27/25 Signaling a possible future approach to regulating Schedule II-V prescribing via telemedicine in lieu of in-person examinations, on January 17 the DEA issued a notice of proposed rulemaking regarding its next iteration of controlled substance prescribing controls. With comments due March 18, 2025, the Proposed Rule is not subject to the Trump administration’s executive order freeze on new proposed regulations. [Click on the title's link to continue reading.]

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[Sweden] The process of pain assessment in people with dementia living in nursing homes: A scoping review

01/25/25 at 03:00 AM

[Sweden] The process of pain assessment in people with dementia living in nursing homes: A scoping reviewPalliative Care and Social Practice; Caroline Kreppen Overen, Maria Larsson, Adelheid Hummelvoll Hillestad, Ingela Karlsson, Siren Eriksen; 1/25Studies have documented a pain prevalence in people with dementia living in nursing homes of 35%–43%, but a possible prevalence of 60%–80%. This scoping review provides a comprehensive description of pain assessment in people with dementia living in nursing homes as a process in three steps. Self-reported information is the most appropriate when assessing pain, as symptom experience is subjective and highly personal. However, for people with dementia living in nursing homes, self-reporting represents a challenge due to cognitive impairment, including difficulties with language and communication. People with dementia might express pain with different behavioural expressions or signs, such as agitation, apathy, restlessness or wandering. Numerous observational assessment tools targeting pain in people with dementia have been developed and evaluated and systematic use of standardized observational tools has been recommended.

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Transforming care: Spencer Health Solutions and Pharmerica partner to simplify medication management and improve lives

01/23/25 at 03:00 AM

Transforming care: Spencer Health Solutions and Pharmerica partner to simplify medication management and improve lives The MarCom Journal, Morrisville, NC; by Leigh White, PharMerica and Daphne Earley, Spencer Health Solutions; 1/21/25In a move set to redefine how medication is managed, Spencer Health Solutions (SHS), a leader in innovative healthcare technology, and PharMerica, one of the nation’s largest and most trusted long-term care pharmacy services provider, are joining forces. This transformative partnership aims to make managing medications easier and more reliable for individuals with complex medication needs, senior living communities, and payers nationwide. ... Spencer Health Solutions (SHS) is dedicated to transforming medication management through innovative healthcare technology. ... PharMerica ... serves the long-term care, senior living, hospital, home infusion, hospice, behavioral, specialty and oncology pharmacy markets. 

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North Augusta hospice nurse arrested after allegedly using fake prescriptions

01/23/25 at 03:00 AM

North Augusta hospice nurse arrested after allegedly using fake prescriptions Aiken Standard, Aiken, SC; by Matthew Christian; 1/22/25 A North Augusta hospice nurse has been arrested after allegedly acquiring prescription drugs with fake prescriptions. South Carolina Bureau of Drug Control agents arrested Amy Elizabeth Strand, 44, on Jan. 17, according to an Aiken County Sheriff's Office booking report. Strand obtained lorazepam 2 mg tablets from the North Augusta Kroger on June 22, 2024, Agent B.A. Stafford said in a warrant. ... To get the pills, Strand called in a fake prescription in the name of a patient under her care, Stafford continued. ... Strand has been charged with three counts of obtaining a controlled substance by fraud and one count of attempting to obtain a controlled substance by fraud. 

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Lobbying groups unite to form US Cannabis Roundtable

01/20/25 at 03:00 AM

Lobbying groups unite to form US Cannabis Roundtable MJBiz; by MJBizDaily Staff; 1/16/25 The National Cannabis Roundtable and the U.S. Cannabis Council – two large lobbying groups that advocate on behalf of the state-regulated marijuana industry in Washington, D.C. – are merging to form the US Cannabis Roundtable. The unified group represents marijuana multistate operators such as Cresco Labs, Curaleaf Holdings, Green Thumb Industries, Trulieve Cannabis Corp. and Verano Holdings as well as single-state operators, according to a [recent] news release. 

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[Korea] A prospective, single-cohort, open, multi-center, observational study of sublingual fentanyl for breakthrough cancer pain: Effectiveness, safety, and tolerability in Korean cancer patients

01/11/25 at 03:05 AM

[Korea] A prospective, single-cohort, open, multi-center, observational study of sublingual fentanyl for breakthrough cancer pain: Effectiveness, safety, and tolerability in Korean cancer patientsCancer Research and treatment; Youn Seon Choi, Su-Jin Koh, Woo Kyun Bae, Se Hyung Kim, Seong Hoon Shin, So Yeon Oh, Sang Byung Bae, Yaewon Yang, Eun-Kee Song, Yoon Young Cho, Pyung Bok Lee, Ho-Suk Oh, MinYoung Lee, Jin Seok Ahn; 12/24Fentanyl, a highly lipophilic opioid, was developed as a sublingual fentanyl tablet (SFT) for the management of breakthrough cancer pain (BTcP), and its efficacy and safety were confirmed in a randomized, controlled study. In a real-world setting, SFT provides rapid and effective analgesia in BTcP, even at the lowest dose (100 μg), and the safety profile was acceptable.

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Methadone in cancer-related neuropathic pain: A narrative review

01/04/25 at 03:25 AM

Methadone in cancer-related neuropathic pain: A narrative reviewCurrent Oncology; Faten Ragaban, Om Purohit, Egidio Del Fabbro; 12/24The unique mechanisms of action and preliminary clinical trials support methadone's status as the first opioid to consider for CRNP [cancer-related neuropathic pain] when non-opioid first-line treatments have failed to alleviate patient symptoms. Methadone can also be considered as a first-line opioid in patients with mixed nociceptive-neuropathic pain and any of the following features: renal dysfunction; administration of opioids through a feeding tube; a lack of financial resources/insurance; and a switch from another high-dose opioid. More research is needed regarding methadone for CRNP and methadone's preferential use in specific sub-groups of patients.

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PBMs secretly profited from opioid crisis: New York Times

12/27/24 at 03:00 AM

PBMs secretly profited from opioid crisis: New York Times Becker's Hospital Review; by Alexandra Murphy; 12/17/24 Pharmacy benefit managers were paid by drugmakers, including Purdue Pharma, to keep opioid prescriptions flowing even as overdose deaths soared across the U.S., according to an investigation by The New York Times. The Dec. 17 report highlighted how Express Scripts, CVS Caremark and Optum Rx, which control access to medications for millions of Americans, negotiated deals with opioid manufacturers to prevent restrictions on painkiller prescriptions in exchange for lucrative rebates. Between 2003 and 2012, Purdue Pharma paid PBMs roughly $400 million annually to avoid limits on opioid prescriptions, which included measures that could have curtailed overprescribing, such as requiring additional physician justifications or limiting the number of pills dispensed. Internal documents reviewed by the Times show how the PBMs repeatedly collaborated with opioid manufacturers to influence insurers' decisions and block restrictions.

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[KY] Attorney General Russell Coleman files lawsuit against Optum Rx for role in opioid epidemic

12/03/24 at 03:00 AM

[KY] Attorney General Russell Coleman files lawsuit against Optum Rx for role in opioid epidemic Northern Kentucky Tribune - Kentucky Center for Public Service Journalism; 12/1/24 The Kentucky Attorney General’s Office has announced its latest lawsuit against a corporation behind the worst man-made epidemic in modern medical history. Attorney General Russell Coleman added Optum Rx and its affiliates to the list of those responsible for the opioid crisis. ... According to the Attorney General’s lawsuit, Optum Rx played a central role in the reckless promotion, dispensing, and oversupply of opioids. ... “Defendants have hidden their conduct through non-transparent business practices and by requiring each entity with whom they conduct business, such as opioid manufacturers, to enter into confidentiality agreements or otherwise keep their agreements confidential,” said the lawsuit. “No state has been harder hit by the drug crisis than Kentucky. Last year alone, nearly 2,000 Kentuckians died of a drug overdose,” Attorney General Coleman said. “These groups pushed a profit-fueled agenda at the expense of Kentucky families, who are left with empty seats at the dinner table. Our Office will continue to hold those behind the drug crisis accountable for their devastating actions.”

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Official collaboration between IAHPC and INCB

11/21/24 at 03:00 AM

Official collaboration between IAHPC and INCB ehospice; 11/19/24 The International Association for Hospice and Palliative Care (IAHPC) is pleased to announce that it has signed a Memorandum of Understanding (MoU) with the International Narcotics Control Board (INCB). The purpose of the MoU is “to provide a framework of cooperation and understanding and to facilitate collaboration to further their shared goals and objectives in regard to improving the availability of internationally controlled substances for medical and scientific purposes.” ... The objectives laid out in the MOU include among others, the exchange of research, data, and analysis on an annual basis on controlled medicines and the exploration of possible solutions such as joint activities to make such information available to the international community. These objectives will be achieved through regular dialogues between INCB and the IAHPC.

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The power of collaboration: Pharmacists and nurses partner to enhance patient care

09/26/24 at 03:00 AM

The power of collaboration: Pharmacists and nurses partner to enhance patient care American Society of Health-System Pharmacists (ASHP) News Center; by Karen Blum; 9/23/24 Pharmacists and nurses work together on today's most pressing health challenges - from managing heart failure to deprescribing in palliative care to tackling obesity in pre-transplant patients. The Collaborative Care Grant for Nurses and Pharmacists from the ASHP Foundation and American Nurses Foundation recognizes the potential impact of this interdisciplinary teamwork on improving healthcare outcomes. At UPMC Presbyterian Hospital, the grant program helped fund the creation of a medication optimization clinic (MOC) for those with heart failure with reduced ejection fraction. “It made a lot of sense to bring together our collective expertise to manage these patients to get them on more optimal medications,” said James Coons, a clinical pharmacist in cardiology at UPMC Presbyterian Hospital. Coons, an ASHP member and professor at the University of Pittsburgh School of Pharmacy, worked with nurse practitioner and longtime collaborator, Jennifer Kliner, on the project.

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Too Much, Too Little, Just Right: Optimizing cancer care for older adults

09/11/24 at 03:15 AM

Too Much, Too Little, Just Right: Optimizing cancer care for older adults The ASCO Post, American Society of Clinical Oncology; by Ramy Sedhom, MD; Bobby Green, MD; and Julia  Frydman, MD, MS; 9/10/24 Imagine walking into a fancy restaurant only to find a menu consisting mostly of kids’ dishes. It would make no sense. Just 25% of restaurant diners are younger than age 12, and they rarely write Yelp reviews. But when it comes to cancer treatment, this is not very far from what we do. The median age for a new cancer diagnosis is 67, and among those who die of cancer each year, 73% are older adults. Yet just one in four clinical trial participants is aged 70 or older. Consequently, guidelines for most new cancer therapies are based on a median age that is significantly younger than the patient population who actually receives these therapies. That’s quite a conundrum. More than half of patients older than age 65 experience toxicity of grade 3 or worse while undergoing standard chemotherapy. ... Palliative Care—For a 40-year-old mother of two young children, the goal of cancer treatment is usually clear: complete remission and long-term survival. But when you ask older patients with cancer about their priorities, a majority regard symptom control, emotional coping, and other quality-of-life measures at least as much as longevity and sometimes more.

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Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathy

08/24/24 at 03:15 AM

Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathyPalliative Care and Social Practice; by Mellar P Davis; 7/24This review will discuss haloperidol, miragabalin, palmitoylethanolamide (PEA), and clonidine as adjuvant analgesics or analgesics. Haloperidol [demonstrates] ... only low-grade evidence that [it] improves pain when combined with morphine, methadone, or tramadol in patients who have cancer, pain from fibrosis, radiation necrosis, or neuropathic pain. Miragabalin is a gabapentinoid approved for the treatment of neuropathic pain ... [and] in randomized trials, patients with diabetic neuropathy have responded to miragabalin. Multiple randomized trials and meta-analyses have demonstrated PEA's effectiveness in reducing pain severity arising from diverse pain phenotypes. Intravenous clonidine has been used in terminally ill patients with poorly controlled symptoms, in particular pain and agitation.

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The importance of competencies in pain management and palliative care

08/23/24 at 03:00 AM

The importance of competencies in pain management and palliative care Greenwich Sentinel, Greenwich, CT; by Russell R. Barksdale, Jr.; 8/21/24 ... Competencies, ongoing pharmacological education, regular patient pain assessments, management, and medication adjustments are all crucial processes for healthcare providers in today’s complex medical environment. Regrettably, metabolic and behavioral issues related to pain medications, especially opioids, if not properly managed, poses risk of addiction. Beginning in the late 1990s, the consumption of medical opioids used to treat pain increased in many countries worldwide. Since that time, alarmingly the United States has outpaced every other country in per capita opioid consumption. ... [Click on the title's link to continue reading.]

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