Literature Review

All posts tagged with “Research News.”



Crowdsourced feedback to improve resident physician error disclosure skills-A randomized clinical trial

08/24/24 at 03:25 AM

Crowdsourced feedback to improve resident physician error disclosure skills-A randomized clinical trialJAMA Open Network; Andrew A. White, MD; Ann M. King, MA; Angelo E. D’Addario, MA; Karen Berg Brigham, JD, MPH; Joel M. Bradley, MD; Thomas H. Gallagher, MD; Kathleen M. Mazor, Ed; 8/24Residents must prepare for effective communication with patients after medical errors. The video-based communication assessment (VCA) is software that plays video of a patient scenario, asks the physician to record what they would say, engages crowdsourced laypeople to rate audio recordings of physician responses, and presents feedback to physicians. In this randomized clinical trial, self-directed review of crowdsourced feedback was associated with higher ratings of internal medicine and family medicine residents’ error disclosure skill, particularly for those without real-life error disclosure experience, suggesting that such feedback may be an effective way for residency programs to address their requirement to prepare trainees for communicating with patients after medical harm.

Read More

Palliative rehabilitation in patients with cancer: definitions, structures, processes and outcomes

08/24/24 at 03:20 AM

Palliative rehabilitation in patients with cancer: definitions, structures, processes and outcomesCurrent Oncology Reports; by Jegy M. Tennison, Jack B. Fu, David Hui; 8/24This review examines the literature on palliative rehabilitation for patients with advanced cancer, focusing on definitions, structures, processes, and outcomes. Palliative cancer rehabilitation emphasizes a collaborative approach that integrates palliative care with rehabilitation interventions, aiming to enhance quality of life and address diverse patient needs. The outcomes of palliative cancer rehabilitation varied widely by goals, settings, and interventions. Studies in hospice settings generally reported improved symptom control; inpatient rehabilitation had mixed functional outcomes; and outpatient palliative rehabilitation may contribute to enhanced functional and symptom outcomes, especially among patients with higher baseline function.

Read More

Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathy

08/24/24 at 03:15 AM

Novel drug treatments for pain in advanced cancer and serious illness: a focus on neuropathic pain and chemotherapy-induced peripheral neuropathyPalliative Care and Social Practice; by Mellar P Davis; 7/24This review will discuss haloperidol, miragabalin, palmitoylethanolamide (PEA), and clonidine as adjuvant analgesics or analgesics. Haloperidol [demonstrates] ... only low-grade evidence that [it] improves pain when combined with morphine, methadone, or tramadol in patients who have cancer, pain from fibrosis, radiation necrosis, or neuropathic pain. Miragabalin is a gabapentinoid approved for the treatment of neuropathic pain ... [and] in randomized trials, patients with diabetic neuropathy have responded to miragabalin. Multiple randomized trials and meta-analyses have demonstrated PEA's effectiveness in reducing pain severity arising from diverse pain phenotypes. Intravenous clonidine has been used in terminally ill patients with poorly controlled symptoms, in particular pain and agitation.

Read More

A protocol for the inclusion of minoritized persons in Alzheimer Disease research from the ADNI3 Diversity Taskforce

08/24/24 at 03:10 AM

A protocol for the inclusion of minoritized persons in Alzheimer Disease research from the ADNI3 Diversity TaskforceJAMA Open Network; by Ozioma C Okonkwo, Monica Rivera Mindt, Miriam T Ashford, Catherine Conti, Joe Strong, Rema Raman, Michael C Donohue, Rachel L Nosheny, Derek Flenniken, Melanie J Miller, Adam Diaz, Annabelle M Soto, Beau M Ances, Maryam R Beigi, P Murali Doraiswamy, Ranjan Duara, Martin R Farlow, Hillel T Grossman, Jacobo E Mintzer, Christopher Reist, Emily J Rogalski, Marwan N Sabbagh, Stephen Salloway, Lon S Schneider, Raj C Shah, Ronald C Petersen, Paul S Aisen, Michael W Weiner, Alzheimer’s Disease Neuroimaging Initiative; 8/24Black or African American (hereinafter, Black) and Hispanic or Latino/a/x (hereinafter, Latinx) adults are disproportionally affected by Alzheimer disease, but most research studies do not enroll adequate numbers of both of these populations. The Alzheimer's Disease Neuroimaging Initiative-3 (ADNI3) launched a diversity taskforce to pilot a multipronged effort to increase the study inclusion of Black and Latinx older adults. In this cross-sectional study of pilot inclusion efforts, a culturally informed, community-engaged approach increased the inclusion of Black and Latinx participants in an Alzheimer disease cohort study.

Read More

Palliative care is a viable option for frail elderly patients with neurocognitive disorders admitted for hip fractures

08/24/24 at 03:05 AM

Palliative care is a viable option for frail elderly patients with neurocognitive disorders admitted for hip fractures BMC Musculoskeletal Disorders; by Justine Boulet, Etienne L Belzile, Norbert Dion, Chantal Morency, Mélanie Bérubé, Alexandra Tremblay, Stéphane Pelet; 8/10/24 Most patients presenting with a hip fracture regardless of their comorbidities are surgically treated. A growing body of research states that a certain type of elderly patient could benefit more from a palliative approach. ... The presence of [a nuerocognitive disorder] NCD and diminished prefracture autonomy strongly support counseling for palliative care. The high rate of complications when surgery is proposed for frail patients with multiple comorbidities suggests that the concept of palliative surgery needs to be revisited. 

Read More

Does a patient’s ability to pay for health care make their life worth saving?

08/24/24 at 03:00 AM

Does a patient’s ability to pay for health care make their life worth saving?JAMA Open Network; by Zara Cooper, MD, MSc; 7/24In this well-executed study using data from the American College of Surgeons Trauma Quality Improvement Program (TQIP), Hoit et al demonstrated that the timing of withdrawal of life-sustaining treatment (WLST) in critically injured adults between ages 18 and 64 years was statistically associated with the type of insurance they carried. Specifically, the authors showed that even after accounting for patient and hospital characteristics, individuals without insurance were approximately 50% more likely to undergo WLST earlier than others who were insured (eg, private insurance or Medicaid). ... it is incumbent upon individual clinicians and health systems to closely and uncomfortably examine how bias either creeps or marches into the life-and-death decisions we make for everyone under our care.

Read More

Protecting patients and society in an era of private equity provider ownership: Challenges and opportunities for policy

08/24/24 at 03:00 AM

Protecting patients and society in an era of private equity provider ownership: Challenges and opportunities for policyHealth Affairs; by Christopher Cai, Zirui Song; 5/24Private equity (PE) acquisitions in health care delivery nearly tripled from 2010 to 2020. Despite concerns around clinical and economic implications, policy responses have remained limited. We discuss the US policy landscape around PE ownership, using policies in the European Union for comparison. We present four domains in which policy can be strengthened.

Read More

The Hastings Center awarded $1.5 million by PCORI to study organizational trustworthiness and community-engaged research

08/19/24 at 03:00 AM

The Hastings Center awarded $1.5 million by PCORI to study organizational trustworthiness and community-engaged research  EurekAlert! AAAS; Susan Gilbert, The Hastings Center; 8/13/24 A research team at The Hastings Center has been approved for $1.5 million in funding by the Patient-Centered Outcomes Research Institute (PCORI) to study organizational trustworthiness as it relates to community-engaged research. Led by Virginia A. Brown, PhD, a research scholar at The Hastings Center, the study will be the first to investigate the role of organizational trustworthiness in shaping research engagement processes and outcomes. 

Read More

Connected to the cloud at time of death: a case report

08/17/24 at 03:40 AM

Connected to the cloud at time of death: a case reportJournal of Medical Case Reports; by Isabel Straw, Claire Kirkby, Preethi Gopinath; 8/24Our case report provides the first clinical evaluation of autopsy practices for a patient death that occurs on the cloud. We question how autopsy practices may require adaptation for a death that presents via the 'Internet of Things', examining how existing guidelines capture data related to death which is no longer confined to the patient's body... Through this patient case we explore novel challenges associated with digital deaths including; (1) device hardware issues (difficult extraction processes, impact of pathological tissue changes), (2) software and data limitations (impact of negative body temperatures and mortuary radio-imaging on devices, lack of retrospective cloud data analysis), (3) guideline limitations (missing digital components in autopsy instruction and death certification), and (4) changes to clinical management (emotional impact of communicating deaths occurring over the internet to members of family). Publisher's note: An interesting article posing interesting questions about the impact technology has on death and the potential use / misuse of health information gathered by devices.

Read More

End-of-life care for the devout Jewish patient

08/17/24 at 03:35 AM

End-of-life care for the devout Jewish patientJournal of Evaluation in Clinical Practice; by Jennifer Eitingon, Danielle Doberman, Zackary Berger, Corey Xavier Tapper; 8/24This case illustrates the ethical tensions that may arise when Western medical practices intersect with Orthodox Jewish beliefs, particularly regarding brain death, resuscitation, and artificial nutrition. We underscore the need for cultural sensitivity when approaching EOL decision-making, allowing for compassionate and comprehensive care that respects religious perspectives. This paper helps provide a structure for clinicians to navigate the complex EOL care needs for the devout Jewish patient in a manner consistent with their cultural and religious identity.

Read More

African American patient and caregiver attitudes and perceptions of community health workers as lay patient navigators in palliative care

08/17/24 at 03:30 AM

African American patient and caregiver attitudes and perceptions of community health workers as lay patient navigators in palliative care Annals of Palliative Medicine; by Olivia Monton, Shannon Fuller, Amn Siddiqi, Alison P Woods, Taleaa Masroor, Robert Joyner, Ronit Elk, Jill Owczarzak, Fabian M Johnston; 8/5/24 Underutilization of palliative care services, especially among African American patients with advanced cancer, remains an important public health problem. To address this gap, we developed a community health worker (CHW) palliative care intervention for African American patients with advanced cancer, which is being formally assessed through an ongoing effectiveness-implementation trial. ... Results: Overall, there was a lack of awareness and understanding of palliative care, due primarily to limited experiences with palliative care services among study participants. Despite this lack of familiarity, participants recognized the potential benefits of palliative care for patients with advanced cancer.  

Read More

Roles of Chaplains and Clergy in Spiritual Care for African Americans in Hospice: A Pilot Study

08/17/24 at 03:25 AM

Roles of chaplains and clergy in spiritual care for African Americans in hospice: a pilot studyAmerican Journal of Hospice and Palliative Care; by Denise D Quigley, Sara G McCleskey, Jason Lesandrini, Natalie McNeal, Nabeel Qureshi; 8/24 

Read More

Special considerations in managing pain and psychosocial distress in patients with opioid use disorder and cancer: the role of the supportive care and psycho-oncology interdisciplinary team

08/17/24 at 03:20 AM

Special considerations in managing pain and psychosocial distress in patients with opioid use disorder and cancer: the role of the supportive care and psycho-oncology interdisciplinary teamAnnals of Palliative Medicine; by M Catherine Trimbur, Bridget Sumser, Chelsea Brown, Timothy Steinhoff, Khaldoun Almhanna, Dana Guyer; 7/24People with a substance use disorder (SUD) have shortened lifespans due to complications from their substance use and challenges engaging with traditional health care settings and institutions. This impact on life expectancy is especially prominent in patients with co-occurring SUDs and cancer, and often has a much worse prognosis from the cancer than a similar patient without a SUD. Palliative care teams are experts in serious illness communication and symptom management and have become increasingly embedded in the routine care of patients with cancer. We argue that the skill set of palliative care teams is uniquely suited for addressing the needs of this oft marginalized group.

Read More

Physical, emotional, and practical symptom burden in patients with terminal illnesses

08/17/24 at 03:15 AM

Physical, emotional, and practical symptom burden in patients with terminal illnessesAnnals of Palliative Medicine; by Charles B. Simone II; 7/24End of life care can best be optimized by understanding the scope of symptom burden that patients face with end-stage diseases. As this symptom burden differs for different terminal conditions—from cancer to heart disease to neurological or kidney or pulmonary diseases, for example—it is critical to understand the symptoms and overall holistic effects that each diseases places on patients. The Integrated Palliative care Outcome Scale (IPOS) is a widely used and validated patient-reported tool consisting of 17 items (10 measuring physical symptoms, 4 measuring emotional symptoms, and 3 measuring communication/practical issues) rated on a 5-point Likert scale. Fordjour and colleagues (1) identified some important differences across terminal conditions ... Finally, this study identified groups at higher risk of suffering from a greater symptom burden, including older patients, female patients, married or cohabitating patients, and patients who live alone, thus providing healthcare providers with information from which they can prioritize resources for these patient populations.

Read More

Symptom burden and quality of life among patient and family caregiver dyads in advanced cancer

08/17/24 at 03:10 AM

Symptom burden and quality of life among patient and family caregiver dyads in advanced cancerQuality of Life Research; by Katrina R Ellis, Allison Furgal, Feyisayo Wayas, Alexis Contreras, Carly Jones, Sierra Perez, Dolapo Raji, Madeline Smith, Charlotte Vincent, Lixin Song, Laurel Northouse, Aisha T Langford; 7/24Symptom management among patients diagnosed with advanced cancer is a high priority in clinical care that often involves the support of a family caregiver. This study seeks to identify patient and caregiver symptom clusters and investigate associations between identified clusters and demographic, clinical, and psychosocial factors (cognitive appraisals and [quality of life] QOL). The most prevalent symptom for patients was energy loss/fatigue and for caregivers, mental distress. Higher symptom burden was associated with more negative appraisals of the cancer and caregiving experience, and poorer QOL (physical, social, emotional, functional, and overall QOL). Dyads whose caregivers had more chronic conditions were more likely to be in the high symptom burden subgroup.

Read More

Pain management inequities by demographic and geriatric-related variables in older adult inpatients

08/17/24 at 03:05 AM

Pain management inequities by demographic and geriatric-related variables in older adult inpatientsJournal of the American Geriatrics Society; by Aksharananda Rambachan, Torsten B Neilands, Leah Karliner, Kenneth Covinsky, Margaret Fang, Tung Nguyen; 7/24Pain is ubiquitous, yet understudied. The objective of this study was to analyze inequities in pain assessment and management for hospitalized older adults focusing on demographic and geriatric-related variables. Conclusion: Older, hospitalized, general medicine patients from minoritized groups and with geriatric-related conditions are uniquely vulnerable to inequitable pain assessment and management. These findings raise concerns for pain underassessment and undertreatment.

Read More

Hospital assets before and after private equity acquisition

08/10/24 at 03:40 AM

Hospital assets before and after private equity acquisitionJAMA; by Elizabeth Schrier, Hope E M Schwartz, David U Himmelstein, Adam Gaffney, Danny McCormick, Samuel L Dickman, Steffie Woolhandler; 7/24Private equity firms spent $505 billion on health care acquisitions between 2018 and 2023. Financial infusions may augment resources for care. However, firms have sometimes sold acquired hospitals’ land and buildings, repaying investors with proceeds and burdening hospitals with rent payments for facilities they once owned. We assessed changes in hospitals’ capital assets after private equity acquisition. After private equity acquisition, hospital assets decreased by 24% relative to that of controls during 2 years. Private equity acquisitions appear to have depleted, rather than augmented, hospital assets. Although funds from asset drawdowns might be redeployed to enhance care or efficiency, previous studies suggest such effects may not occur.

Read More

Changes in registered nurse employment plans and workplace assessments

08/10/24 at 03:35 AM

Changes in Registered Nurse Employment Plans and Workplace AssessmentsJAMA Network Open; by Christopher R Friese, Barbara R Medvec, Deanna J Marriott, Lara Khadr, Marissa Rurka Wade, Melissa Riba, Marita G Titler; 7/24How have nurses’ workplace assessments and intention to leave their workplace changed from the 2022 to the 2023 Michigan Nurses’ Study? In this survey study of 9150 and 7059 nurse participants in the 2022 and 2023 surveys, respectively, significantly fewer nurses were planning to leave their workplace in 2023 than in 2022 (32.0% vs 39.1%). Workplace assessments improved in the 2023 survey; however, planned departure rates, abusive or violent events, and unsafe conditions remained high, and understaffing remained a primary concern. Findings of this study suggest that improved working conditions are likely to promote nurse retention; health system leaders and policymakers should prioritize initiatives that support nurse retention and reduce potential workforce instability.

Read More

AI and health insurance prior authorization: Regulators need to step up oversight

08/10/24 at 03:30 AM

AI And Health Insurance Prior Authorization: Regulators Need To Step Up OversightHealth Affairs; by Carmel Shachar Amy Killelea Sara Gerke; 7/24Artificial intelligence (AI)—a machine or computer’s ability to perform cognitive functions—is quickly changing many facets of American life, including how we interact with health insurance. AI is increasingly being used by health insurers to automate a host of functions, including processing prior authorization (PA) requests, managing other plan utilization management techniques, and adjudicating claims. In contrast to the Food and Drug Administration’s (FDA’s) increasing attention to algorithms used to guide clinical decision making, there is relatively little state or federal oversight of both the development and use of algorithms by health insurers.

Read More

Kidney transplant outcomes from deceased donors who received dialysis

08/10/24 at 03:25 AM

Kidney Transplant Outcomes From Deceased Donors Who Received DialysisJAMA Network; by Yumeng Wen, Sherry G Mansour, Nityasree Srialluri, David Hu, Heather Thiessen Philbrook, Isaac E Hall, Mona D Doshi, Sumit Mohan, Peter P Reese, Chirag R Parikh; 5/24Are kidneys from deceased donors who underwent dialysis prior to kidney donation associated with adverse graft outcomes in kidney transplant recipients compared with kidneys from deceased donors who did not undergo dialysis? Compared with recipients of kidneys from deceased donors who did not undergo dialysis, receiving kidneys from deceased donors who underwent dialysis prior to donation was associated with a higher incidence of delayed graft function, but no difference in graft failure or death at longer-term follow-up.

Read More

Improving pain self-management among rural older adults with cancer

08/10/24 at 03:20 AM

Improving Pain Self-Management Among Rural Older Adults With CancerJAMA Network; by Megan J Shen, Tammy Stokes, Sarah Yarborough, Jill Harrison; 7/24Is the adapted version of Cancer Health Empowerment for Living without Pain (CA-HELP) feasible, acceptable, and able to improve pain outcomes among older adults with cancer living in rural settings? Study results highlight a potentially low-cost, low-burden intervention designed to improve pain communication and reduce pain severity and pain misconceptions among older adults with cancer in rural settings.

Read More

Managing medications among individuals with mild cognitive impairment and dementia: Patient-caregiver perspectives

08/10/24 at 03:15 AM

Managing medications among individuals with mild cognitive impairment and dementia: Patient-caregiver perspectivesJournal of the American Geriatrics Society, by Rachel O'Conor, Andrea M Russell, Allison Pack, Dianne Oladejo, Sarah Filec, Emily Rogalski, Darby Morhardt, Lee A Lindquist, Michael S Wolf; 7/24With changing cognitive abilities, individuals with mild cognitive impairment (MCI) and dementia face challenges in successfully managing multidrug regimens. We sought to understand how individuals with MCI or dementia and their family caregivers manage multidrug regimens and better understand patient-to-caregiver transitions in medication management responsibilities. To ease medication management transitions, balance must be sought between preservation of older adult autonomy and early family caregiver involvement. Clinicians should work to initiate conversations with family caregivers and individuals living with MCI or dementia about transitioning medication responsibilities as memory loss progresses, simplify regimens, and deprescribe, as appropriate.

Read More

Social isolation changes and long-term outcomes among older adults

08/10/24 at 03:10 AM

Social isolation changes and long-term outcomes among older adultsJAMA Network Open; by Chen Lyu, Katherine Siu, Ian Xu, Iman Osman, Judy Zhong; 7/24Is social isolation change associated with long-term outcomes in older adults? In this cohort study using a national longitudinal health survey of 13 649 adults aged 50 years or older in the US, data revealed that increased isolation was associated with an increased risk of mortality, disability, and dementia. Decreased isolation was associated with a lower risk of mortality only among individuals who were non-isolated at baseline. These results underscore the importance of interventions targeting the prevention of increased isolation among older adults to mitigate its adverse effects on mortality, as well as physical and cognitive function decline.

Read More

Four years and more than 200,000 deaths later: Lessons learned from the COVID-19 pandemic in US nursing homes

08/10/24 at 03:05 AM

Four Years And More Than 200,000 Deaths Later: Lessons Learned From The COVID-19 Pandemic In US Nursing HomesHealth Affairs; by R. Tamara Konetzka, David C. Grabowski, Vincent Mor; 7/24Nursing home residents and staff were disproportionately affected by the COVID-19 pandemic, drawing attention to long-standing challenges of poor infection control, understaffing, and substandard quality of care in many facilities. Evolving practices and policies during the pandemic often focused on these challenges, with little effect. Despite the emergence of best practices to mitigate transmission of the virus, even the highest-quality facilities experienced outbreaks, indicating a larger systemic problem, rather than a quality problem at the facility level. Here we present a narrative review and discussion of the evolution of policies and practices and their effectiveness, drawing on evidence from the United States that was published during 2020–23.

Read More

Start of the COVID-19 pandemic and palliative care unit utilization: a retrospective cohort study

08/10/24 at 03:00 AM

Start of the COVID-19 pandemic and palliative care unit utilization: a retrospective cohort studyJournal of Pain and Symptom Management; by Michael Bonares, Kalli Stilos, Madison Peters, Lise Huynh, Debbie Selby; 7/24Despite historically poor palliative care units (PCU)/hospice access, the COVID-19 pandemic created circumstances that may have enabled unprecedented utilization in individuals with non-cancer diagnoses in our cohort. This substantiates that so long as it is concordant with their goals, individuals with non-cancer diagnoses can have enhanced PCU/hospice utilization.

Read More