[Kazakhstan] Mechanisms of chronic pain in Alzheimer's Disease: A narrative review

[Kazakhstan] Mechanisms of chronic pain in Alzheimer's Disease: A narrative review
Current Medicinal Chemistry; by Roman Konovalov, Mina Aubakirova, Dmitriy Viderman; 4/25
AD [Alzheimer's Disease] causes structural and functional alterations in the affected brain, including shrinkage of gray matter volume and disruptions in brain network connectivity. Besides memory loss, pain is a significant yet often neglected symptom. Effective pain management in AD is challenged by the adverse effects of pain-relief medications and communication difficulties, especially as the disease progresses. Pharmacological options include opioids, nonsteroidal anti-inflammatory drugs, paracetamol/acetaminophen, and adjuvant pain relievers like antidepressants and antiepileptic medications, though these are not officially approved for pain relief in AD. Non-pharmacological strategies, such as exercise therapy, music therapy, Reiki, reflexology, and behavioral therapy, are preferred to prevent the side effects of medication. The review highlights a crucial link between neurological changes in AD and the perception of pain, underscoring the need for customized pain management approaches for this population.