Literature Review

[Italy] Fever in a palliative care setting: Clinical insights and implications from a prospective observational cohort studyPalliative Medicine; by Stefania Cheli, Elena Angeli, Oscar Corli, Sofia Dinegro, Agostino Zambelli, Tania Carta, Romina Shazivari, Michaela Smolikova, Paolo Franceschi, Francesco Molà, Yara Silva Cruzeiro, Emilio Clementi, Andrea Gori; 5/26Fever is a frequent but complex symptom in adults with a limited prognosis, arising from multifactorial causes beyond infection. The study was conducted in an inpatient hospice palliative care unit within the Luigi Sacco Hospital in Milan, Italy (January and December 2024). Fever occurred in 40% of patients, with a median onset of 5.5 days after admission. In 39.7% of cases, fever was attributed to infections, mainly catheter-associated urinary tract infection. Its strong association with medical devices highlights the need for proportional, personalised interventions that primarily consider prognosis, symptom relief, and quality of life.

Emotional and ethical impacts on healthcare professionals performing cardiopulmonary resuscitationAmerican Journal of Hospice & Palliative Medicine; by Patrick J. Macmillan, Susan Hughes, Dumindra Gurusinghe, Allison Go, Chase Lancaster, Iris Price; 6/26Many studies exist outlining poor outcomes related to cardiopulmonary resuscitation (CPR) administered to patients who are elderly and/or have comorbid medical conditions with sudden cardiac arrest. Studies show only 10% of patients with out-of-hospital cardiac arrest and initial asystole survive until they reach the hospital. Less than 5% survive until hospital discharge with good neurologic function. This study presents data that suggests that there is an association between moral distress and performing CPR on individuals who are elderly with multiple comorbid medical conditions. More than sixty percent of our respondents were challenged emotionally during these types of code situations, and a similar number of healthcare workers felt the code could be considered unethical.

Cardiologists treating increasingly complex patients as America ages Medscape; by Sarah Amandolare; 7/14/26 ... Heart failure (HF) affects 15%-20% of adults over 80, according to the American Heart Association/American College of Cardiology/Heart Failure Society of America Guideline for the Management of Heart Failure. HF with preserved ejection fraction (HFpEF), which becomes more likely after age 80, is related to other common conditions of aging, including hypertension, chronic kidney disease, diabetes, and obesity. “Almost by definition, most people that have HFpEF have multiple comorbidities,” Hummel said. “You have to account for a lot of them when you’re thinking about how to help the patient best.” This population also has higher chances of developing dementia and frailty, which affect 35% of adults age 90 and older and 31% of octogenarians, respectively. Older adults hospitalized for HF also have a high likelihood of polypharmacy; 68% take 10 or more medicines.

Palliative care for older adults with hip fracture: An explanatory sequential mixed-methods studyJournal of Pain & Symptom Management; by Daniel I Hoffman, Sydney Moore, Amanda J Reich, Christina Sheu, Mengyuan Ruan, Masami Tabata-Kelly, Kate Sciacca, Tamryn F Gray, Daniel Dohan, Charlotta Lindvall, Zara Cooper; 6/26After hip fracture, older adults experience burdensome treatments and high mortality; they may therefore benefit from palliative care (PC). Among 1,433 hip fracture admissions, GOCC [goals of care conversations], hospice discussions, and specialty PC were documented in view on their role in GOCC. Conclusion: Limited standardization, role uncertainty, and cultural factors limited PC documentation and delivery, highlighting opportunities to strengthen PC integration in surgical care.

The hidden cost of cancer's end: how financial strain shapes final months of care Fred Hutch Cancer Center, University of Washingon, Seattle, WA; by D. Moosavi; 6/25/26 ... Previous Fred Hutch research has shown that people with cancer are more than twice as likely to file for bankruptcy, and nearly twice as likely to experience what researchers call an “adverse financial event,” compared with people who don’t have cancer. But most of that earlier work focused on financial hardship as an outcome caused by cancer. This study flips the question: once someone is already dealing with financial strain, what happens to the care they receive as their illness progresses? 

7 ways palliative care can help people with ATTR-CMEveryday Health; by Abby McCoy, RN; 7/3/26 Transthyretin cardiac amyloidosis (ATTR-CM), a rare type of heart failure, can cause symptoms that affect more than just your heart, and many of them can lower your quality of life. But palliative care, or care meant to provide symptom relief, comfort, and support, can help you live better with this condition. ... Here’s how your palliative care team can help you manage life with ATTR-CM and feel your best.

Family caregivers' perspectives on challenges and support needs in hospital-based palliative care for persons living with dementia Baylor Medicine | Texas Medical Center Documents ; by Jung Kwak, Anita Chary, Sarah Stayer, Kwaku Duah Oppong, Sumin Yoon, Snehal Patel, and Elizabeth A Kvale; originally pub 11/17/25, reposted online 6/23/26Palliative care needs of hospitalized persons living with dementia (PLWD) and their family caregivers remain poorly understood. ... Thematic analysis of interviews revealed three themes: the value of palliative care in navigating end-of-life uncertainty in dementia, uncoordinated and reactive care during hospitalization, and lack of guidance for post-hospital transitions. While caregivers valued palliative care for emotional and decision-making support, findings underscore the need for earlier integration and improved coordination across hospital teams to better support families.