Literature Review

Neuropalliative care in movement disordersContinuum: Lifelong Learning in Neurology; by Benzi M Kluger; 12/25Over the past decade, significant progress has been made to advance palliative care approaches for patients with Parkinson disease and other movement disorders. This population has significant palliative care needs that are poorly met under traditional models of care, including nonmotor symptom management, advance care planning, psychosocial support, spiritual and existential support, care partner support, and timely referrals for specialist and end-of-life palliative care (hospice). Clinical trials demonstrate that specialist palliative care can improve many patient and family outcomes. Neurologists can use the five-pillars framework (nonmotor symptoms, advance care planning, psychosocial and spiritual support, care partner support, and timely involvement of specialist palliative care) to systematically address common sources of suffering that are poorly recognized in traditional models of care. This framework can be integrated into previsit screening forms and note templates to improve the detection of palliative issues.

Documentary sheds light on HIV patient’s science-advancing ‘last gift’ through UCSD study San Diego Union Tribune; by Noah Lyons; 12/30/25 The documentary "The Last Gift" follows Jim Dunn's end-of-life decision to donate his tissues to HIV research, highlighting the altruistic act of giving back to science. The film showcases Jim's journey and the impact of his final act on advancing HIV research. It is a poignant reminder of the power of individual generosity in the pursuit of medical breakthroughs. 

Is Alzheimer’s disease more common than previously thought? Medscape; by Megan Brooks; 12/24/25 Alzheimer’s disease (AD) may be more common than previously thought in some demographic groups, according to the first population-based study to use a blood test to gauge AD-related neuropathological changes (ADNCs). ... A “major advance” of this study is the use of blood-based biomarkers as a way to generate more accurate, population-level estimates of AD pathology, Nicholas Ashton, PhD, senior director of the Banner Fluid Biomarker Program, Banner Sun Health Research Institute in Sun City, Arizona, told Medscape Medical News.

323.3: What happens after the gift? Insights from organ procurement organizations on strengthening aftercare in the United StatesTransplantation; by Levan, Macey; Akhtar, Jasmine; Sidoti, Carolyn; Kaplow, Katya; Klitenic, Samantha; Flower, Tessa; Yusef, Bola; Vanterpool, Karen; Parent, Brendan; Koons, Brittany; 12/25Each of the 55 U.S. organ procurement organizations (OPOs) is responsible for obtaining authorization for donation and supporting donor families through the donation process. While federal regulations mandate certain responsibilities related to authorization and coordination, there is no regulatory requirement that OPOs provide services to families after donation. Nonetheless, most OPOs have developed “aftercare” programs, which historically have focused on honoring loved ones, commemorating donation, and offering limited grief-related support. Facilitators of meaningful aftercare included peer connection efforts, standardized data processes, and tailoring services to diverse family needs. However, the structure, scope, and intensity of these programs vary widely, and there has been little national attention to standardizing or modernizing aftercare efforts. Common barriers to effective aftercare included limited access to mental health resources, low survey response rates, insufficient staffing or funding, and fragmentation between initial and long-term support teams. 

Translating the value of palliative transfusions for patients with blood cancers into high-quality end-of-life careJAMA Network Open; by Pamela Egan, Dana Guyer; 11/25Studies have described how patients with blood cancers enroll in hospice care at lower rates than patients with solid tumor cancers, receive more futile chemotherapy, are more likely to seek emergency care at the EOL [end of life] , are more likely to be treated in intensive care units, and are more likely to die in hospital settings than their counterparts with solid tumors. The Medicare hospice benefit is structured in such a way that providing transfusions is cost prohibitive for hospice agencies. It is time to heed the call from the American Society of Hematology and palliative care and hospice agencies nationwide to revise the Medicare hospice benefit such that patients with blood cancers can receive hospice care as soon as their cancer-directed treatments are no longer valuable without sacrificing the quality-of-life–sustaining transfusions. This will be an important step toward ensuring high-quality EOL care for patients with hematologic malignant neoplasms.

Precision Radiation Oncology Rhode Island and HopeHealth Hospice & Palliative Care announce Collaborative partnership Today in Business, Providence, RI; Press Release; 12/30/25 Precision Radiation Oncology Rhode Island (PRORI) ... along with HopeHealth, provider of palliative care and hospice services, are proud to announce a new collaborative partnership, aimed at improving quality of life and Precision outcomes for patients undergoing cancer care, beginning January 2026. This collaboration brings together two organizations with complementary missions: delivering state-of-the-art cancer treatment while ensuring compassionate, patient-centered support throughout every stage of the patient’s cancer journey. By working closely together, in a synergistic manner, PRORI and HopeHealth will provide a seamless continuum of cancer care that addresses not only the clinical aspects of cancer treatment, but also the physical, emotional, and psychosocial needs of patients, their families and caregivers.

Early palliative care interventions linked with reduced mortality in patients with advanced NSCLC undergoing ICI treatment Lung Cancers Today; by Cecilia Brown; 12/24/25 Early palliative care interventions were associated with reduced mortality and longer survival among patients with advanced non–small cell lung cancer who received immune checkpoint inhibitors (ICIs), according to a recent study. Researchers from the Case Western Reserve University School of Medicine and University Hospitals Seidman Cancer Center presented the study findings at the International Association for the Study of Lung Cancer (IASLC) and American Society of Clinical Oncology (ASCO) 2025 North America Conference on Lung Cancer.

[Saudi Arabia] Comparison of end-of-life care between patients with hematological malignancies versus solid tumors: A retrospective analysisJournal of Palliative Care; by Salma Almusaed, Kim Sadler, Walaa Abdulmutaali, Gassan Abudari, Steven Callaghan, Mahmoud Sroor, Muneerah Almutairi, Mohammed AlGhamdi, Muruf Zaid Alshalwah, Sameer Desai, Nessreen Abu Alsalhm, Khloud Alzain; 11/25While specialized palliative care (PC) is well-established for managing STs [solid tumors], its integration into HMs’ [hematological malignancies] care remains less common despite evidence of its benefits. The cohort consisted of 350 adult patients, of whom 86 (24.6%) had HMs and 264 (75.4%) had STs. Overall, HMs patients received more aggressive end-of-life care, including higher rates of Intensive Care Unit (ICU) admissions (81.4% vs 17.8%), intubation (36% vs 8.3%), disease-modifying treatments (23% vs 3.8%), as well as more enteral feeding, dialysis, blood transfusions, and antimicrobial use. Their resuscitation discussions occurred closer to death (3 vs 16 days ... ). Additionally, HMs patients had fewer referrals to PC services (43% vs 79.2% ... ), and most of them died in the ICU (59.3% vs 18.2% ... ).

Terminally ill Stanford professor teaches class about dying from cancerCBS News, Bay Area, CA; by Elizabeth Cook; 3/13/25 A Stanford University professor's new curriculum explores the multiple aspects and phases of a person dying of cancer, and it comes from a person with first-hand knowledge. Dr. Bryant Lin has been a professor for almost two decades. He's used to being the teacher, not the subject of his classes. But that all changed in 2024 when he was diagnosed with stage 4 lung cancer. ... The diagnosis was a dose of cruel irony. Lin co-founded the Center for Asian Health Research and Education. One of the priorities for the foundation is researching non-small cell adenocarcinoma, also known as "never-smoker lung cancer," the same cancer diagnosis that Lin received. ... The class is called "From diagnosis to dialogue: A doctor's real-time battle with cancer." Within minutes of being posted, the class and the waitlist were full. ... The 10-week course covers the entire spectrum of cancer as seen through the eyes of someone who is living it. ... Stanford University recorded every session of the class so that they could live on for future physicians. If you would like to watch them, they can be found on YouTube. 

Home Health Aides caring for adults with heart failure-A pilot randomized clinical trialJAMA Network Open; by Madeline R. Sterling, Cisco G. Espinosa, Sasha Vergez, Margaret V. McDonald, Joanna Ringel, Jonathan N. Tobin, Samprit Banerjee, Nicola Dell, Lisa M. Kern, Monika M. Safford; 11/25Objective: To examine the effectiveness of an education- and communication-based intervention among HHAs caring for patients with HF.  In this pilot randomized clinical trial including 102 agency-employed HHAs randomized to training alone or in addition to an application that allowed HHAs to exchange text messages with nurse supervisors, training improved HHAs’ HF knowledge and HF caregiving self-efficacy. The addition of the application did not improve these primary outcomes, but it significantly reduced HHAs’ self-reported preventable 911 calls, a secondary outcome.

Managing competing interests between appointed surrogates and extended family in end-of-life care available to purchaseAmerican Academy of Pediatrics; by Derek R. Soled, Elizabeth Lanphier, Ianthe R.M. Schepel, Maya Scott; 11/25This Ethics Rounds article brings together perspectives from a clinical ethicist, 2 resident physicians in pediatrics, and a social worker on a case involving a terminally ill, intubated, and sedated young adult patient whose health care proxy, extended family, and health care team disagree on the course of her care. Although the proxy, the patient’s adult sister, seems to agree in principle with the health care team’s recommendation to withdraw life-sustaining treatment, she is unwilling to consent to withdrawal due to perceived pressure from her extended family. From an ethics perspective, we discuss the concept of the “marginalized decision-maker” and how to blend the “best interests” approach from pediatric medicine with the “substituted judgment” standard applied in adult medicine when making decisions for incapacitated young adult patients. From a clinical perspective, we explore features of this case that may contribute to feelings of moral distress within the medical team, identify best practices for leading team and family meetings to avoid values imposition and promote shared decision-making, and argue for the importance of training physicians in clinical ethics and reflective skills to improve the quality of patient care and reduce experiences of moral distress in the workplace. Finally, we explore the role that family dynamics, families’ culture and values, and past experiences in the health care system can play in shared decision-making conversations.