Literature Review

Family caregivers' perspectives on challenges and support needs in hospital-based palliative care for persons living with dementia Baylor Medicine | Texas Medical Center Documents ; by Jung Kwak, Anita Chary, Sarah Stayer, Kwaku Duah Oppong, Sumin Yoon, Snehal Patel, and Elizabeth A Kvale; originally pub 11/17/25, reposted online 6/23/26Palliative care needs of hospitalized persons living with dementia (PLWD) and their family caregivers remain poorly understood. ... Thematic analysis of interviews revealed three themes: the value of palliative care in navigating end-of-life uncertainty in dementia, uncoordinated and reactive care during hospitalization, and lack of guidance for post-hospital transitions. While caregivers valued palliative care for emotional and decision-making support, findings underscore the need for earlier integration and improved coordination across hospital teams to better support families.

[Portugal] Reiki and Therapeutic Touch for symptom burden and quality of life in palliative settings: A systematic reviewPalliative Medicine; by Raquel Pontes-Gomes, Paulo Reis-Pina; 5/26Evidence regarding Reiki and Therapeutic Touch in palliative and end-of-life care remains limited and heterogeneous. Nine studies involving 415 participants were included: five mixed-methods studies, three randomized controlled trials, and one qualitative cross-sectional study conducted in North America (n = 6) and Europe (n = 3). Cancer was the predominant diagnosis.  Some studies reported improvements in symptoms (pain, anxiety, depression, fatigue, and stress), and in quality-of-life domains (sleep, relaxation, energy, hope, and emotional well-being). Qualitative findings described perceived relaxation, comfort, and emotional support. Further well-designed studies are needed to clarify their potential role in palliative care.

Symptom-monitoring app helps patients with advanced cancer maintain quality of life The ASCO Post; by The ASCO Post Staff; 6/2/26 Use of a mobile app for proactive symptom monitoring helped patients with advanced cancer who were no longer receiving active anticancer treatment maintain their quality of life and reduced hospital utilization, according to findings from a randomized controlled trial presented at the 2026 ASCO Annual Meeting. The study evaluated SUPPORT+, a digital symptom-monitoring platform designed for patients receiving palliative care. The app sends weekly automated reminders prompting patients—or their caregivers—to complete a brief questionnaire about physical and emotional symptoms. Based on responses, the app provides self-management recommendations for mild or moderate symptoms and automatically alerts palliative care nurses when severe or worsening symptoms are reported. Nurses then follow up with patients through the app or by telephone.

Ketamine for depression in serious illness: Evidence, safety, and practical approachesJournal of Pain & Symptom Management; by Paul Noufi, Joshua B. Borris, Danielle Chammas, Cara L. McDermott, Nneka N. Ufere, Jason A. Webb, Daniel Shalev; 4/26Patients with serious illness and short prognoses often experience depression and suicidal ideation. Traditional antidepressants are limited by delayed onset, creating a need for rapidly acting therapies. Ketamine and esketamine [nasal spray] offer the strongest evidence among rapid-acting antidepressants and may be preferred when urgent symptom relief is needed. However, rigorous psychiatric trials in serious illness are lacking. Clinicians should consider prognosis, access to Risk Evaluation and Mitigation Strategies-certified esketamine programs or equivalent regulatory frameworks outside the US, and the need for an appropriate maintenance regimen when integrating ketamine into palliative care depression management.

Potential adjunctive role of osteopathic manipulative medicine in the management of cancer-related bone pain: A narrative reviewCureus; by Ambrose Loc T. Ngo, Niki Gharavi Alkhansari, Chi Pham, Hong Nguyen, Monica Rubi, David Tanner; 4/26Osteopathic manipulative medicine (OMM) is known for its therapeutic potential on the musculoskeletal system, and its emerging role and potential benefits in oncology care are gaining attention. Patients with primary and metastatic bone cancer tend to experience pain, restricted movement, and lower quality of life due to the pathology and its treatment. This narrative review examines the mechanistic rationale and available clinical evidence supporting the use of OMM in the management of pain and functional impairment among patients with bone malignancies. Limited clinical studies suggest that select OMM techniques, including myofascial release (MFR), gentle soft tissue methods, and lymphatic approaches, may contribute to improvements in pain perception, mobility, and fatigue in oncology populations.