Literature Review

Experiences and knowledge of family caregivers providing end of life care to older adults at home American Journal of Hospice and Palliative Medicine; by Delaney E. Knutson, BSN and Barbara St Marie, PhD, AGPCNP, FAANP, FAAN; 1/28/26 Conclusion: This scoping review highlighted the need for increased information for family caregivers regarding end-of-life care to reduce the challenges and burden for families caring for their older adult at home at end-of-life. Areas for improvement include increased support from family and friends, caregiver respite, increased education about caregiving, and improved communication between hospice programs and home caregivers. 

Medical Aid in Dying and our ethical duties—Call to actionJAMA Health Forum; by Yesne Alici, Liz Blackler, Julia Danielle Kulikowski, Amy Scharf; 1/26Medical aid in dying (MAID) is legal in 11 US states and Washington, DC, and is being actively considered in 18 additional states ... In all jurisdictions where MAID is legal, hospital systems have the option to opt out of providing MAID services but are legally obligated to share information about where patients can access resources. We maintain that all hospital systems and individual clinicians have an ethical responsibility to go beyond simply sharing information. Patients are going to ask about MAID, and institutions are ethically obligated to establish comprehensive policies that empower and encourage their clinical staffs—primarily physicians but also nurses and advanced practice clinicians—to purposefully and thoughtfully respond. Here, we describe the experience of our institution, Memorial Sloan Kettering Cancer Center (MSK), in developing policies and procedures to fulfill this responsibility and highlight lessons for other health care organizations and oncology practices seeking to accomplish similar goals.

Preparing for the inevitable: a scoping review of death and dying education in U.S. medical schoolsAcademic Medicine; by Logan Patterson, Autumn Decker, Angelique King, Anna Roman, Cory Bolkan, Raven H Weaver; 1/26There remains a sizeable gap in evidence-based medical education related to knowledge, skills, and abilities pertaining to end-of-life care. The authors offer next steps for developing, implementing, and measuring evidence-based interventions to improve end-of-life care competency. The authors advocate for continued implementation of evidence-based educational interventions, regardless of anticipated specialty area, throughout all preclinical and clinical years.

Researchers identify new blood markers that may detect early pancreatic cancer; NIH-funded, four-marker panel could one day help catch one of deadliest cancers at more treatable stagesNIH press release; 1/30/26National Institutes of Health (NIH)-supported investigators have developed a blood test to find pancreatic ductal adenocarcinoma, one of the deadliest forms of cancer. The new test could improve survival rates from pancreatic cancer, which tends to be diagnosed at late stages when therapy is less likely to be effective. The findings were published in Clinical Cancer Research. Overall, only about 1 in 10 pancreatic cancer patients survive more than five years from diagnosis. However, experts expect that when the cancer is found and treated at an earlier stage, survival would improve. While finding the cancer early is key, there are no current screening methods to do so.

Hospice clinicians' approaches to terminal restlessness: A qualitative analysisJournal of Pain & Symptom Management; Andy Jan, Molly Turnwald, Susan Maixner, Thomas O'Neil, Lauren Gerlach; 1/26Terminal restlessness is frequently observed in hospice, yet it lacks a consistent definition, diagnostic framework, and treatment approach. Five themes emerged [from this study]: (1) Diagnostic challenge-clinicians reported difficulty distinguishing terminal restlessness from delirium, pain, or medication side effects; (2) Common symptom profile-agitation, confusion, hallucinations, and constant movement; (3) Temporal association with active dying process-terminal restlessness was viewed as a sign of imminent death; (4) Ruling out reversible causes-pain, urinary retention, or other modifiable factors; and (5) Treatment variability-approaches varied, though most clinicians were more comfortable using sedating medications once death was perceived to be imminent.

[UK] The effects of music interventions on behavioural and psychological symptoms in older adults with dementia: Systematic reviewAdvances in Mental Health; by Motunrayo A. Akinboye, Benjamin O. Ajibade; 12/25Dementia, affecting over 55 million people globally, often presents with behavioural and psychological symptoms (BPSDs) such as agitation, depression, and anxiety. Pharmacological treatments can lead to adverse effects, highlighting theneed for safer, non-drug alternatives like music interventions. Findings show that music interventions significantly alleviated symptoms such as depression, anxiety, and agitation. Both active (e.g., singing, playing instruments) andreceptive (e.g., listening) music therapy formats were effective, with sessions ranging from 20–90 minutes. Interventions were most successful when personalized and culturally tailored.

Exploring Artificial Intelligence in hospice and palliative care: An integrative review of technological and clinical Journal of Palliative Medicine; by Tuzhen Xu, PhD, APRN, FNP-C, Caiyi Liu, PhD, BSN, RN, Lin Li, PhD, Dan Song, PhD, RN, Gloria M. Rose, PhD, NP-C, FNP-BC, and Sen Zhu, PhD; 2/4/26 Conclusions: AI holds potential in enhancing timely, patient-centered palliative and hospice care, supporting prognostication, symptom management, and decision-making. Successful integration requires attention to clinician trust, workflow alignment, equity, and ethical considerations. To maximize its impact on underutilization, future research should focus on multicenter validation, representative datasets, ethical deployment, and seamless integration into clinical practice.

Comment on the 2025 Global Map of Palliative Care: Data clarity and consistencyJournal of Pain & Symptom Management; by Guangwei Ji, Jin Ke, Fei Sun; 12/25We read with great interest the findings from the "First-Ever Global Ranking of Palliative Care: 2025 World Map Under the New WHO Framework" published in November 2025. As the first comprehensive review post the COVID-19 pandemic, this article provides an updated mapping of palliative care development worldwide. The use of a new WHO framework in 201 countries and territories, offers an invaluable overview on the global state of palliative care, particularly inspirational for countries that are launching palliative care policies or programs.

Concurrent care and equity: Addressing palliative care gaps for African American men in rural communities with a serious respiratory illnessAmerican Journal of Hospice & Palliative Medicine; by Cathy L. Campbell; 12/25Hospice and palliative care are often hard to access for African Americans (AA) living in rural areas with serious respiratory illnesses. Under the Medicare Hospice Benefit, patients must stop curative or life-sustaining treatments for their terminal illness, which limits options for concurrent care. This is a major challenge for AA men, whose average life expectancy is 67.8 years—about 10 years shorter than the national average. They also experience more care transitions in the last 6 months of life compared to White and Hispanic patients. These frequent transitions show how fragmented the health system is and how it often fails AA families. Using intersectionality and a vignette, this paper explores how overlapping factors—lived experience as AA man, rural location, and serious illness—affect access to palliative care.

A qualitative study of chaplains spiritual care for persons with dementia in long-term careJournal of Applied Gerontology; by Meganne K. Masko, Sarah McEvoy, Jung Kwak, Kathryn Lyndes, Alexia M. Torke, Shelley Varner Perez, George Fitchett; 12/25This study explored how chaplains provide spiritual care for residents with dementia in long-term care, which is not well understood. We conducted six separate semi-structured focus groups with a total of 16 chaplains who provide care for people with dementia in long-term care facilities across the U.S. Two main themes emerged: the broad and multifaceted role of chaplains in long-term care, including responsibilities to residents, staff, and family, and dementia-specific spiritual care adaptations and delivery practices, including learning through experience, using multisensory tools, relying on presence, music, and emotional resonance. Chaplains’ adaptive, person-centered spiritual care for residents with dementia highlights the need for dementia-informed chaplaincy training and greater integration of chaplaincy into interdisciplinary care planning in long-term care settings.

[Australia] Cancer and dementia incidence are strongly correlated worldwide: Evidence from cross-national regression analysesFuture Science OA; by Wenpeng You, Brendon J Coventry, Maciej Henneberg; 12/25Cancer and dementia are two major health problems affecting millions of people around the world. Countries with higher cancer rates almost always have higher dementia rates. Even after we accounted for income, life expectancy, and other social factors, cancer remained one of the strongest predictors of dementia. These findings suggest that cancer and dementia share many of the same underlying causes, such as aging, chronic inflammation, lifestyle habits, and changes that come with economic development. Understanding these shared patterns can help countries plan for future healthcare needs.

Evaluating palliative care needs in patients with advanced non-malignant chronic conditions: An umbrella review of needs assessment tools Healthcare; by Chrysovalantis Karagkounis, Stephen Connor, Danai Papadatou, Thalia Bellali; 12/24/25 Patients with advanced non-malignant chronic conditions experience illness burdens and palliative care needs comparable to those of oncology patients, yet palliative care is often introduced late. Identifying individuals with potential palliative care needs is complex, and although multiple tools exist, the most appropriate approach for assessing needs in this population remains unclear. This umbrella review aimed to identify and evaluate tools used to systematically assess palliative care in adults with advanced non-malignant chronic conditions, with a specific focus on their content, structure, and psychometric properties.