Literature Review

Researchers identify new blood markers that may detect early pancreatic cancer; NIH-funded, four-marker panel could one day help catch one of deadliest cancers at more treatable stagesNIH press release; 1/30/26National Institutes of Health (NIH)-supported investigators have developed a blood test to find pancreatic ductal adenocarcinoma, one of the deadliest forms of cancer. The new test could improve survival rates from pancreatic cancer, which tends to be diagnosed at late stages when therapy is less likely to be effective. The findings were published in Clinical Cancer Research. Overall, only about 1 in 10 pancreatic cancer patients survive more than five years from diagnosis. However, experts expect that when the cancer is found and treated at an earlier stage, survival would improve. While finding the cancer early is key, there are no current screening methods to do so.

Hospice clinicians' approaches to terminal restlessness: A qualitative analysisJournal of Pain & Symptom Management; Andy Jan, Molly Turnwald, Susan Maixner, Thomas O'Neil, Lauren Gerlach; 1/26Terminal restlessness is frequently observed in hospice, yet it lacks a consistent definition, diagnostic framework, and treatment approach. Five themes emerged [from this study]: (1) Diagnostic challenge-clinicians reported difficulty distinguishing terminal restlessness from delirium, pain, or medication side effects; (2) Common symptom profile-agitation, confusion, hallucinations, and constant movement; (3) Temporal association with active dying process-terminal restlessness was viewed as a sign of imminent death; (4) Ruling out reversible causes-pain, urinary retention, or other modifiable factors; and (5) Treatment variability-approaches varied, though most clinicians were more comfortable using sedating medications once death was perceived to be imminent.

Effectiveness and impact of telehealth-integrated palliative care for persons living with dementia and their caregiversTelemedicine & e-Health; by Brooke Worster, Lizabeth Kaminoff, Amina Mason, Laura Pontiggia, Kayla Madden, Mackenzie Kemp, Amanda Guth, Nina Diamond, Allison Herens, Kristin Rising, Jeannette Kates; 12/25 In 2024, an estimated 6.9 million Americans aged 65 and older were living with Alzheimer’s disease (AD), the most common form of dementia. Palliative care (PC) can improve quality of life (QOL) and reduce nonbeneficial care, yet persons living with dementia (PLWD) remain underserved. The intervention group [in this study] received up to two telehealth visits with a PC specialist, the patient (if able), and a caregiver (if participating). The intervention group had significantly fewer emergency department visits and hospitalizations but no differences in QOL or caregiver burden.

Exploring Artificial Intelligence in hospice and palliative care: An integrative review of technological and clinical Journal of Palliative Medicine; by Tuzhen Xu, PhD, APRN, FNP-C, Caiyi Liu, PhD, BSN, RN, Lin Li, PhD, Dan Song, PhD, RN, Gloria M. Rose, PhD, NP-C, FNP-BC, and Sen Zhu, PhD; 2/4/26 Conclusions: AI holds potential in enhancing timely, patient-centered palliative and hospice care, supporting prognostication, symptom management, and decision-making. Successful integration requires attention to clinician trust, workflow alignment, equity, and ethical considerations. To maximize its impact on underutilization, future research should focus on multicenter validation, representative datasets, ethical deployment, and seamless integration into clinical practice.

Comment on the 2025 Global Map of Palliative Care: Data clarity and consistencyJournal of Pain & Symptom Management; by Guangwei Ji, Jin Ke, Fei Sun; 12/25We read with great interest the findings from the "First-Ever Global Ranking of Palliative Care: 2025 World Map Under the New WHO Framework" published in November 2025. As the first comprehensive review post the COVID-19 pandemic, this article provides an updated mapping of palliative care development worldwide. The use of a new WHO framework in 201 countries and territories, offers an invaluable overview on the global state of palliative care, particularly inspirational for countries that are launching palliative care policies or programs.

Concurrent care and equity: Addressing palliative care gaps for African American men in rural communities with a serious respiratory illnessAmerican Journal of Hospice & Palliative Medicine; by Cathy L. Campbell; 12/25Hospice and palliative care are often hard to access for African Americans (AA) living in rural areas with serious respiratory illnesses. Under the Medicare Hospice Benefit, patients must stop curative or life-sustaining treatments for their terminal illness, which limits options for concurrent care. This is a major challenge for AA men, whose average life expectancy is 67.8 years—about 10 years shorter than the national average. They also experience more care transitions in the last 6 months of life compared to White and Hispanic patients. These frequent transitions show how fragmented the health system is and how it often fails AA families. Using intersectionality and a vignette, this paper explores how overlapping factors—lived experience as AA man, rural location, and serious illness—affect access to palliative care.

A qualitative study of chaplains spiritual care for persons with dementia in long-term careJournal of Applied Gerontology; by Meganne K. Masko, Sarah McEvoy, Jung Kwak, Kathryn Lyndes, Alexia M. Torke, Shelley Varner Perez, George Fitchett; 12/25This study explored how chaplains provide spiritual care for residents with dementia in long-term care, which is not well understood. We conducted six separate semi-structured focus groups with a total of 16 chaplains who provide care for people with dementia in long-term care facilities across the U.S. Two main themes emerged: the broad and multifaceted role of chaplains in long-term care, including responsibilities to residents, staff, and family, and dementia-specific spiritual care adaptations and delivery practices, including learning through experience, using multisensory tools, relying on presence, music, and emotional resonance. Chaplains’ adaptive, person-centered spiritual care for residents with dementia highlights the need for dementia-informed chaplaincy training and greater integration of chaplaincy into interdisciplinary care planning in long-term care settings.

[Australia] Cancer and dementia incidence are strongly correlated worldwide: Evidence from cross-national regression analysesFuture Science OA; by Wenpeng You, Brendon J Coventry, Maciej Henneberg; 12/25Cancer and dementia are two major health problems affecting millions of people around the world. Countries with higher cancer rates almost always have higher dementia rates. Even after we accounted for income, life expectancy, and other social factors, cancer remained one of the strongest predictors of dementia. These findings suggest that cancer and dementia share many of the same underlying causes, such as aging, chronic inflammation, lifestyle habits, and changes that come with economic development. Understanding these shared patterns can help countries plan for future healthcare needs.

[Sweden] Palliative medicine physicians' experiences using the Numeric Rating Scale for pain assessment in patients with advanced cancer: a qualitative study BMJ Open; by Lisa Martinsson, Margareta Brännström, Per Fransson, Sofia Andersson; 1/6/26 This study aimed to describe palliative medicine physicians' experiences performing pain assessment using the Numeric Rating Scale (NRS)-one of the most widely used pain assessment tools-for patients with cancer receiving specialised palliative care. ... The tool may seem simplistic, but, ... the physicians found interpreting the assessments challenging for the whole team. This complexity should be incorporated into future healthcare education and training within the palliative care area, where patients often have chronic pain conditions in combination with cognitive impairment. Future research needs to focus on developing reliable pain assessment methods for patients who are cognitively impaired because of the cancer.

[Netherlands] Pediatric advance care planning: a mixed-methods evaluation of documentation and sharing in current practice BMC Palliative Care; by Sophie Tooten, Rosella P.M.G. Hermens, Manel Verhoeven, Ellen M. Vierhoven, Fatima Boulakhrif, Jana M. Reintjes, Michel A.A.P. Willemsen, Judith L. Aris-Meijer, Jurrianne C. Fahner, Marijanne Engel, Marijke C. Kars, Inge M.L. Ahout & Esther Deuning-Smit; 1/29/26 Pediatric advance care planning (pACP) aims to align future care and treatment of children with life-limiting conditions (LLCs) with children’s and their families’ values, goals and preferences. Documenting and sharing pACP elements with healthcare professionals (HCPs) is essential for goal-concordant care. This study evaluates how pACP elements are documented in electronic health records of children with LLCs and shared with other HCPs.

"The lack of preparation compounds provider grief": Results from a needs assessment on grief training delivered to pediatric residentsClinical Pediatrics; by Erin Hickey, Erica L Jamro; 12/25Educational interventions to prepare pediatric residents to care for grieving people are rare.  Pediatric residents completed a survey conducted from March to April 2022 that assessed their experience, attitudes, skills, and knowledge of organizational support related to caring for grieving patients and families.  Despite improvements in competence with delivering difficult news with years in residency ... , only 35.7% felt competent by PGY3/4 [post-graduate year 3]. Only 19.5% of residents overall believe adequate grief support exists within their training program. Opportunities for residents to receive formal grief training are inadequate.