Literature Review

All posts tagged with “Research News | Journal Article.”



Use of nebulized tranexamic acid (TA) in combination with nebulized recombinant coagulation factor VIIa to treat hemoptysis in pediatric patients with cancer at end-of-life (EOL)

03/07/26 at 03:35 AM

Use of nebulized tranexamic acid (TA) in combination with nebulized recombinant coagulation factor VIIa to treat hemoptysis in pediatric patients with cancer at end-of-life (EOL)Journal of Pain and Symptom Management; by Santosh Yatam Ganesh, Nelda Itzep, Eduardo Bruera; 2/26Hemoptysis is a distressing symptom for both patients and families at end of life (EOL). In the acute care setting, this can be managed surgically or medically. However, research regarding interventions, such as nebulized tranexamic acid (TA) and nebulized factor VIIa, for palliative management of hemoptysis at EOL is limited. In our case series, we found that combination of nebulized recombinant factor VIIa and nebulized TA relieved hemoptysis in both pediatric cancer patients at the end of life. This case series highlights the potential use of this combination to reduce suffering and distress secondary to hemoptysis in the palliative setting.

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Diversity in health care institutions—Well worth the effort

03/07/26 at 03:30 AM

Diversity in health care institutions—Well worth the effortJAMA Network Open; Marshall Fleurant, Jada C. Bussey-Jones; 2/26The Institute of Medicine’s report, Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care, a comprehensive examination of racial disparities in health care, called for interventions and policy changes to ensure equitable access and quality of care. In this systematic review and meta-analysis, Fremont et al noted that programs that promoted equity, diversity, and inclusion (EDI) were associated with diversifying training programs and academic institutions while enhancing professional development among underrepresented minority groups (eg, Black or Latino/a), including in the fields of midwifery, nursing, and dentistry. These programs also were associated with improving the workforce by increasing staff and trainee retention, improving employee and patient satisfaction, and enhancing trainee self-efficacy. Continuing these initiatives are not only worthwhile but essential to truly improve the nation’s health.

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Exploring the relationship between palliative care knowledge, health concerns, and education among seriously ill older adults and their family caregivers using survey and interview data: A novel approach

03/07/26 at 03:25 AM

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Home health nurses’ perceptions of safety

03/07/26 at 03:20 AM

Home health nurses’ perceptions of safetyHome Health Care Management & Practice; by Kiernan Riley, Kalei Crimi, Michael M. Evans, Natalie Faybisovich, Judith E. Hupcey; 2/26The purpose of this qualitative analysis was to evaluate perceived safety threats and the impact of these treats on home health nurses. Findings included overarching themes of fear and safety. Fear within practicing nurses was a consequence of impaired safety in the home setting. The theme of safety had 2 sub-themes: risks to safety, and nursing actions to enhance safety. Effective training and awareness for nuanced safety concerns, such as when caring for persons with SPMIs in a home setting, are required to enhance nurse safety and retention as well as optimize patient care.

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Values considerations in telemedicine: Pause before shifting

03/07/26 at 03:15 AM

Values considerations in telemedicine: Pause before shiftingJournal of Pain and Symptom Management; by Meaghann S. Weaver, Kenneth A. Berkowitz; 12/25As a contingency standard of care, telemedicine use surged during the COVID-19 pandemic. The Medicare telehealth flexibilities introduced during the COVID-19 pandemic expired in September 2025. Any ongoing sustained pivot to telemedicine warrants purposeful attentiveness to ethical considerations and not just technology use as an end unto itself. Telemedicine has the potential to complement face-to-face care practices and enhance clinical interactions when its use is based on shared values. Values such as access, equity, justice, compassion, autonomy, and dignity warrant thoughtful use of telemedicine. Patients and families need to be able to trust that clinicians and health systems will place patient welfare and shared values above technical convenience. As demonstrated in this case description, upholding values fundamental to the practice of medicine in telemedicine can enhance patient connection and foster trustworthy postpandemic practices.

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Cross-cultural validation of the Refusal of Care Informant Scale (RoCIS) for older adults with dementia in the European Portuguese population

03/07/26 at 03:10 AM

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[Japan] Ethics based educational interventions on end-of-life care for undergraduate nursing students: A scoping review

03/07/26 at 03:05 AM

[Japan] Ethics based educational interventions on end-of-life care for undergraduate nursing students: A scoping reviewInternational Journal of Nursing Studies advances; by Saeko Kutsunugi,Satoko Ono, Misae Ito, Kaho Suda, Siu Ling Chan, John Tai Chun Fung, Claudia Kam Yuk Lai, Kyoko Murakami; 6/26Nurses face various ethical dilemmas and conflicts in end-of-life care; however, there is no evidence of effective undergraduate ethics education on the topic settings to address them. The results suggest that while lectures are effective for acquiring ethical knowledge and attitudes related to EOLC based on ethical competency, simulations are more effective for acquiring practical skills such as communication, self-efficacy, and reflection. Incorporating ethical issues in simulations is hoped to broadly develop ethical practice competencies.

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Dementia, taboo, and the need for a cultural reckoning

03/07/26 at 03:05 AM

Dementia, taboo, and the need for a cultural reckoningJournal of Aging Studies; Kelly Marnfeldt; 3/26Dementia is one of the most feared and misunderstood conditions of our time. Even as public awareness has increased, people living with dementia continue to face exclusion, moral disregard, and systemic neglect. Decades of advocacy, education, and contact-based interventions have sought to reduce stigma. [This study] proposes that dementia becomes stigmatized not only because it is misunderstood, but because it violates cultural expectations of personhood, consistency, and intelligibility. The paper concludes by proposing culturally grounded provocations that imagine what it might look like to reframe how dementia is seen, told, and recognized, both socially and culturally.

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Trajectories of goals of care among patients with advanced cancer in the last two years of life

03/07/26 at 03:00 AM

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[Canada] What about the family? A content analysis of international legislative frameworks and guidelines on assisted dying

03/07/26 at 03:00 AM

[Canada] What about the family? A content analysis of international legislative frameworks and guidelines on assisted dyingPolicy, Politics & Nursing Practice; by Charlotte Boven, Gilla K Shapiro, Liesbeth Van Humbeeck, Let Dillen, Nele Van Den Noortgate, Gary Rodin; 2/26When a person chooses assisted dying, the impact on their family can be profound. Legislation and professional guidelines not only regulate and standardize practice, but also support the delivery of high-quality care. Within this framework, bereavement care plays a vital role by helping families prepare for the death and potentially reducing the risk of prolonged grief. To improve quality care, there is a clear need to better integrate family support into assisted dying guidelines by establishing best practices for bereavement care. Future research should focus on family members' perspectives and needs.

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Investigating the role of occupational therapy in palliative care a literature review

03/06/26 at 03:00 AM

Investigating the role of occupational therapy in palliative care a literature review Home Healthcare Now; by Carlie Liseo, OTD, OTR/L and Daniel Martin, D.Sc., MS, OTR/L; March/April 2026 ... Three themes regarding the provision of occupational therapy (OT) services to palliative care (PC) patients were identified: engaging in meaningful activities to increase quality of life (QOL), symptom management and comfort, and supporting caregivers and client environments. OT can play a pivotal role in catering to PC clients’ needs by promoting occupational engagement, alleviating symptoms, and modifying environments. This review offers recommendations for OT service provision in palliative care, clarifying the profession’s role within multidisciplinary home healthcare teams.

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Clinicians outline strategies to improve cancer care in U.S. prisons

03/06/26 at 03:00 AM

Clinicians outline strategies to improve cancer care in U.S. prisons Oncology Times; by Kumar Das, Dibash PhD; March 2026 Cancer is now the leading cause of death in U.S. prisons, and outcomes for incarcerated patients are markedly worse than for those in the general population. A 2022 study of Connecticut's prison system found that people diagnosed with cancer while incarcerated had 92% higher mortality compared with 16% higher mortality observed in England and Wales. The difference, researchers said, underscores the role of healthcare access and correctional policy in shaping cancer survival.

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Q&A: Why are more Americans under 50 years of age dying of colorectal cancer?

03/04/26 at 03:00 AM

Q&A: Why are more Americans under 50 years of age dying of colorectal cancer? Medscape; by Keith Mulvihill; 2/10/26 First, the good news: Fewer Americans younger than 50 years are dying from cancer vs just a decade ago — reflecting progress in prevention, early detection, and treatment. There is, however, one big exception. Colorectal cancer mortality has been steadily inching up, and the disease now stands as the leading cause of cancer death in this age group, up from the fifth-leading in the early 1990s. ... The outlier is colorectal cancer, where mortality has been rising by about 1% per year since 2005. And it’s a pattern seen in both men and women. ... [The researchers are asked,] "Can you offer some possible reasons for the declining mortality in most of the cancers you studied?" 

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John Bowlby’s theory of attachment and separation: revisiting his original visions after 50+ years, what we know today, and where to go from here?

03/02/26 at 03:00 AM

John Bowlby’s theory of attachment and separation: revisiting his original visions after 50+ years, what we know today, and where to go from here?

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"The best, most difficult thing I've ever done": The complex experiences of palliative and hospice familial caregivers

02/28/26 at 03:45 AM

"The best, most difficult thing I've ever done": The complex experiences of palliative and hospice familial caregiversAmerican Journal of Hospice & Palliative Care; by Hannah Rachiele, Kathryn Levy, Gina Schuster, Sheila Conboy, Pei C Grant, Christopher W Kerr; 2/26Caring for chronically or terminally ill individuals comes with unique challenges and circumstances that are specific to each situation and individual involved. The purpose of the current study was to better elucidate the scope of challenges and benefits attributed to caring for a loved one with a serious, life-limiting illness. Four main themes emerged: (1) Burdens on the Caregiver, (2) Navigating Caregiving, (3) The Positives, and (4) Evolution of Relationships. Findings suggest that family caregivers of individuals with terminal or life-limiting illness experience complex, and often contradictory feelings, which may differ from perceptions by those not providing similar care to a loved one. The data suggest that clinicians working with the caregiving population should explore the duality of caregiving beyond just the anticipated negative impacts.

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Trends and disparities in left ventricular failure mortality in The United States: A 1999-2020 analysis

02/28/26 at 03:35 AM

Trends and disparities in left ventricular failure mortality in The United States: A 1999-2020 analysisJournal of Cardiac Failure; by Abdalhakim Shubietah, Hasan Munshi, Emmanuel Olumuyide, Muath Baniowda, Abdallah Hussein, Mohammad Alqadi, Qutaiba Qafisheh, Majd Oweidat, Omar Hamadi, Mohammad O Abdelhafez; 1/26 Left ventricular failure (LVF) is a significant cause of cardiovascular mortality in the United States. Despite advances in heart failure management, mortality rates have shown a notable increase over time, particularly in recent years. This study examines trends and disparities in LVF-related mortality using data from the CDC WONDER database from 1999 to 2020. LVF-related mortality has increased significantly over the past two decades, particularly after 2010, highlighting a growing public health concern. Disparities persist across sex, race, age groups, urbanization, and geographic regions. The high burden of deaths outside medical facilities suggests a need for enhanced outpatient and palliative care strategies.

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BMI at diagnosis and pre-diagnosis weight loss as predictors of stage and survival in hepatocellular carcinoma

02/28/26 at 03:30 AM

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Health impacts of nursing home staffing

02/28/26 at 03:25 AM

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Determinants of tele-palliative care utilization among heart failure patients

02/28/26 at 03:20 AM

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Palliative care utilization and timing for patients undergoing solid organ transplantation in a large multicenter cohort

02/28/26 at 03:15 AM

Palliative care utilization and timing for patients undergoing solid organ transplantation in a large multicenter cohortTransplantation; by Matthew W Kenaston, Ryan Baldeo, Tyler K Murphy; 1/26Palliative care ... referrals in transplant programs are infrequent, often reactive, and the benefits remain unclear. We retrospectively studied 12,676 heart, liver, lung, and kidney transplants across 3 Mayo Clinic sites (2018-2024). PC encounters were classified as pretransplant (≤1 y before admission), peritransplant (during hospitalization), or posttransplant (≤1 y after discharge). Only 8.3% engaged PC, with patterns varying by organ and timing. Timing of inpatient consultation showed a strong positive correlation with hospital length of stay, and pretransplant PC coincided with higher rates of goals-of-care discussions and fewer hospital interventions. Adapting screening criteria to focus on high-risk recipients, PC was associated with fewer short-term readmissions for heart and lung recipients.

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The roboagents are coming!: The promise and challenge of artificial intelligence advance directives

02/28/26 at 03:10 AM

The roboagents are coming!: The promise and challenge of artificial intelligence advance directivesThe Hastings Center Report; by Jacob M Appel; Jan-Feb 2026Advance directives have historically relied upon human agents. But what happens when a patient appoints an artificial intelligence system as an agent? This essay introduces the idea of roboagents-chatbots authorized to make medical decisions when individuals lose capacity. After describing potential models, including a personal AI companion and a chatbot that has not been trained on a patient's values and preferences, the essay explores the ethical tensions these roboagents generate regarding autonomy, bias, consent, family trust, and physician well-being. This essay then calls for legal clarity and ethical guidance regarding the status of roboagents in light of their potential as alternative health care agents.

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A qualitative study with patients, care-partners, clinicians, and bioethicists to identify ethical considerations of artificial intelligence tools in palliative care

02/28/26 at 03:05 AM

A qualitative study with patients, care-partners, clinicians, and bioethicists to identify ethical considerations of artificial intelligence tools in palliative carePalliative Medicine; by John Y. Rhee, Paul Miller, Zachary Tentor, Amanda Reich, Alexi A. Wright, Charlotta Lindvall; 1/26The use of artificial intelligence (AI) in medicine has surged. Given the sensitive nature of palliative care, it is crucial to apply AI tools in a patient-centered and ethical manner. From the interviews we extracted five main themes: (1) Primacy of the doctor-patient relationship over AI performance; (2) Humans have intuition and nuance that AI lacks; (3) Agreement about the importance of oversight of AI tools; (4) New AI technologies should include a process for patient education; and (5) AI increases efficiency, scalability, and a more unified approach to serious illness. When building and implementing AI-based tools, we recommend: establishing oversight committees; reflecting on the unique contributions of humans to care; proactively educating patients and contextualizing the tools; and ensuring data use is restricted to clinical care.

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[Spain] End-of-life preparedness and emotional suffering in patients and caregivers: Findings from an international cohort study spanning the period before and after death

02/28/26 at 03:05 AM

[Spain] End-of-life preparedness and emotional suffering in patients and caregivers: Findings from an international cohort study spanning the period before and after deathPalliative Medicine; by Clément Meier, Verónica Inés Veloso, Bélen Carballo, Eva Víbora Martín, Pilar Barnestein-Fonseca, Dröfn Birgisdóttir, Valgerður Sigurðardóttir, Ida Korfage, Agnes van der Heide, Vilma A Tripodoro; 1/26Preparing for the end of life is believed to help mitigate emotional suffering for both patients and their caregivers. This study uses data from the international iLIVE project to examine how perceived end-of-life preparedness is associated with emotional suffering among patients and their caregivers before and after death. Feeling fully prepared for the end of life was significantly associated with lower levels of emotional suffering for both patients and caregivers. Among patients, preparedness was linked to reduced emotional suffering at baseline and follow-up. For caregivers, these associations were even more pronounced at baseline, follow-up, and after the patient's death.

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Relearning the world through grief-informed case formulation: A critique of prolonged grief disorder

02/28/26 at 03:00 AM

Relearning the world through grief-informed case formulation: A critique of prolonged grief disorder Journal of Humanistic Psychology; by Eleonora Ramsby Herrera, PhD; 1/31/26 Drawing on existential and humanistic frameworks, this review article critically examines the diagnosis of prolonged grief disorder and questions the usefulness of reducing grieving to a fixed set of symptoms and timelines. ... Rather than viewing grief as a disorder to be treated, the article advocates for understanding it as a natural and potentially transformative human response and argues for integrating grief into the bereaved person’s life story as a way to relearn the world.

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"We are caring for the whole person": A qualitative study of social work's role in palliative cancer care

02/28/26 at 03:00 AM

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