Literature Review
All posts tagged with “Clinical News | Pharmacy & Medication News.”
When less is more: Addressing polypharmacy in high-risk populations
07/08/25 at 03:00 AMWhen less is more: Addressing polypharmacy in high-risk populations Pharmacy Times; by Andrew E. Esch, MD, MBA and Alain Hipensteele; 7/7/25 As digital health tools and artificial intelligence (AI)–powered clinical decision support systems become increasingly embedded in pharmacy workflows, pharmacists are gaining new opportunities to identify and address the risks of polypharmacy—particularly in high-risk populations such as older adults and those receiving palliative care. At the same time, evolving deprescribing guidelines and ongoing drug shortages have underscored the need for coordinated, patient-centered medication management strategies. In this interview with Pharmacy Times®, Andrew E. Esch, MD, MBA, director of the Palliative Care Program Development at the Center to Advance Palliative Care, discusses how pharmacists are using emerging technologies to streamline medication reviews, reduce therapeutic duplication, and engage caregivers in deprescribing conversations.
The role of an inpatient hospice and palliative clinical pharmacist in the interdisciplinary team
07/02/25 at 03:00 AMThe role of an inpatient hospice and palliative clinical pharmacist in the interdisciplinary team Texas Medical Center Documents, published by the American Journal of Hospice and Palliative Medicine; by Jetavia Jones Moody, Ivy O. Poon, and Ursula K. Braun; 6/30/25 Palliative care is a specialized health care service for individuals with serious illness at any stage and can be provided in any setting. Current national consensus developed by palliative care experts recommends the inclusion of pharmacists in an interdisciplinary team (IDT) to provide quality palliative care. However, national registry data report that less than 10% of inpatient palliative teams in the U.S. have a clinical pharmacist. Clinical pharmacists have an impactful role in palliative patients' quality of life by optimizing symptom management, deprescribing, and providing education to the palliative care team as well as patients and their families.
Zuranolone in palliative care: Promise and practicality for the rapid treatment of depression
06/28/25 at 03:30 AMZuranolone in palliative care: Promise and practicality for the rapid treatment of depressionThe American Journal of Hospice & Palliative Care; Eric Prommer; 6/25Zuranolone is an orally available antidepressant classified as a neuroactive steroid. Neuroactive steroids act as positive allosteric modulators for both synaptic and extrasynaptic GABA, making them distinct from currently available drugs targeting major depression and insomnia. By modulating GABA binding sites, neuroactive steroids enhance the function of GABA, which is depressed in major depression. The drug has a rapid onset of action, which differs from currently available antidepressants that are used in palliative care. [This] ... paper will review the pharmacology, pharmacodynamics, safety profile, and clinical studies showing its effectiveness in major depression and how it can potentially be helpful in the palliative care population.
Leading PBMs face increasing scrutiny from states
06/25/25 at 03:05 AMLeading PBMs face increasing scrutiny from statesHealthcare Brew; by Nicole Ortiz; 6/18/25Iowa is the latest to impose limits on how PBMs can operate in the state... It all started when Arkansas Governor Sarah Huckabee Sanders signed a law on April 16 saying any company that owns a pharmacy benefit manager (PBM) would be prohibited from also owning or operating pharmacies in the state. That’s seemingly bad news for the Big 3 PBMs—Cigna Group’s Express Scripts, CVS’s Caremark, and UnitedHealth’s Optum Rx, which collectively control nearly 80% of the market—seeing as they all also operate pharmacy chains. Now the state of Iowa wants to get in on the action, with Governor Kim Reynolds signing a law on June 11 to change how PBMs operate in the state.
[UK] Palliative sedation at the end of life: Practical and ethical considerations
06/19/25 at 08:10 PM[UK] Palliative sedation at the end of life: Practical and ethical considerationsClinical Medicine; Dr Caroline Barry MBBS FRCP LLM FHEA PG Cert; Dr Robert Brodrick MB ChB (Hons) MA MRCP FHEA; Dr Gurpreet Gupta MBBS BSc PG Cert; Dr Imranali Panjwani LLB, PGDip, PG Cert, PhD; 6/25Highlights: The aim of palliative sedation is to relieve refractory suffering with the use of medications to reduce consciousness. Where palliative sedation is being used to treat agitation at the end of life, it is important to exclude and/or address reversible causes prior to starting medication. The drug, dose and route of administration of palliative sedation may vary according to the indication for treatment. Appropriate and proportionate use of palliative sedation does not hasten death. Suffering may have different meanings for people depending on their backgrounds and life experiences.
Dr. Anne Merriman obituary: doctor known as ‘mother of palliative care in Africa’
06/19/25 at 03:00 AMDr. Anne Merriman obituary: doctor known as ‘mother of palliative care in Africa’ The Times, London, England; 6/18/25 Dr. Anne Merriman revolutionised palliative and end-of-life care in Africa after developing a cheap form of oral morphine with a Singapore hospital pharmacist. ... Universally known as “Dr. Anne”, she said: “It’s easier than baking a cake.” She developed the pain-controlling recipe after seeing terminally ill patients discharged from hospital because “nothing more could be done for them”. Many died at home in severe and prolonged pain. “A wild, undisciplined schoolgirl” who became a nun and a doctor, Merriman founded the pioneering Hospice Africa Uganda (HAU) in 1993 at the age of 57. Palliative care was largely unknown in Africa when she started her work in Uganda. HAU has treated more than 35,000 patients and trained more than 10,000 healthcare professionals from 37 African countries in the so-called Merriman model. ... Anne Merriman, doctor, was born on May 13, 1935. She died from respiratory failure on May 18, 2025, aged 90.
A single academic site study of five years evaluating pharmacy students’ palliative care clinical reasoning using Script Concordance Testing
06/07/25 at 03:40 AMA single academic site study of five years evaluating pharmacy students’ palliative care clinical reasoning using Script Concordance TestingAmerican Journal of Hospice ad Palliative Medicine; Florence Labrador, PharmD-c; Kyle P. Edmonds, MD, FAAHPM; Toluwalase A. Ajayi, MD, FAAP, FAAHPM; Rabia S. Atayee, PharmD, BCPS, APh, FAAHPM; 5/25This study aimed to evaluate the impact of a Pain and Palliative Care elective didactic course on enhancing clinical reasoning skills among Doctor of Pharmacy (PharmD) students using the Script Concordance Test (SCT). The elective course was offered six times, covering various palliative care topics such as opioid management, procedural pain, and end-of-life care. The study found a statistically significant improvement in SCT scores from pre- to post-course assessments ... This study demonstrates the effectiveness of a targeted palliative care elective in improving clinical reasoning skills among pharmacy students.
MLN Fact Sheet: Creating an effective hospice Plan of Care
05/30/25 at 03:00 AMMLN Fact Sheet: Creating an efffective Hospice Plan of CareCenters for Medicare & Medicaid Services, Medicare Learning Network (MLN); 5/10/25 The hospice plan of care (POC) maps out needs and services given to a Medicare patient facing a terminal illness, as well as the patient’s family or caregiver. CMS data shows that some hospice POCs are incomplete or not followed correctly. This fact sheet educates on creating and coordinating successful hospice POCs. The primary goal of hospice care is to meet the holistic needs of an individual and their caregiver and family when curative care is no longer an option. To support this goal:
WHO unveils new guideline to improve global access to controlled medicines
05/29/25 at 03:00 AMWHO unveils new guideline to improve global access to controlled medicines World Health Organization; by Departmental update; 5/26/25 The World Health Organization (WHO) has released a rapid communication outlining its comprehensive new guideline on balanced national policies for controlled medicines. The guideline’s recommendations were officially presented during a high-level side event at the Seventy-eighth World Health Assembly on Friday 23 May 2025. It is designed to support countries in ensuring safe, equitable and affordable access to essential controlled medicines which are critical for treating acute and chronic pain, mental health conditions, substance use disorders and other serious health issues.
Spouses accused of prescription fraud: Nurse took meds from hospice patients, deputies say
05/27/25 at 03:00 AMSpouses accused of prescription fraud: Nurse took meds from hospice patients, deputies say The Daily Record; by Staff; 5/22/25 A hospice nurse and her husband are accused of diverting and trafficking controlled prescription medications from several pharmacies during her employment at Liberty Home Health and Hospice. Juana Nicole Hull, 42, is charged with six counts of conspiring to traffic opium or heroin and four counts each of obtaining a controlled substance through fraud; embezzling or diverting a controlled substance; and trafficking opioids. Her husband, 38-year-old Robert Wayne Hull, is charged with six counts each of obtaining a controlled substance through fraud and trafficking opioids.
The Mentorship Model: Cultivating resilience and leadership in palliative care pharmacy
05/27/25 at 03:00 AMThe Mentorship Model: Cultivating resilience and leadership in palliative care pharmacy Pharmacy Times; by Alana Hippensteele; 5/22/25 Key Takeaways
New Mexico legalizes medical use of psilocybin
05/22/25 at 03:30 AMNew Mexico legalizes medical use of psilocybin JD Supra; by Patrick Clark and Jennifer Pacicco; 5/20/25 On April 7, 2025, New Mexico became the third state to legalize psilocybin (colloquially known as “magic mushrooms” or “shrooms”) for medical purposes. New Mexico is the first state to legalize psilocybin via legislation and not a ballot initiative, like its predecessors Colorado and Oregon. Under the new law—the “Medical Psilocybin Act”—the following qualifying conditions are listed as eligible for psilocybin treatment: “(1) major treatment-resistant depression; (2) post-traumatic stress disorder; (3) substance use disorders; (4) end-of-life care.” The law also allows the New Mexico Department of Health to promulgate regulations that would add qualifying conditions to that list. ... Employers are not required to accommodate employees under the influence of psilocybin at work.
Texas lawmakers pass bills to expand Medical Marijuana Program and support psychedelic research
05/14/25 at 03:00 AMTexas lawmakers pass bills to expand Medical Marijuana Program and support psychedelic research Marijuana Moment; by Tom Angell; 5/13/25 The Texas House of Representatives has passed bills to significantly expand the state’s limited medical cannabis program and to support research on the therapeutic potential of ibogaine with the aim of encouraging federal approval of the psychedelic. The marijuana measure cleared the House on third reading with a vote of 122–21 and the ibogaine legislation was approved 138-2. The body’s action sends both proposals to the Senate and comes one day after the bills were given initial approval on second reading. ... A second amendment approved by members would require doctors who issue medical cannabis recommendations to report them to the state’s prescription drug monitoring program.
Pharmacist-led care in palliative settings: Using anticholinergics thoughtfully and compassionately
05/06/25 at 03:00 AMPharmacist-led care in palliative settings: Using anticholinergics thoughtfully and compassionately Pharmacy times; by Diana Violanti, PharmD, Pamela S. Moore, PharmD, BCGP, and Alana Hippensteele; 5/5/25 The use of anticholinergic agents to manage terminal secretions, often referred to as the death rattle, remains a nuanced and evolving area of end-of-life care. While these medications are frequently used in hospice and palliative care settings to reduce secretion-related sounds that may be distressing to caregivers, their efficacy in improving patient comfort is less clear and often debated. ... Diana Violanti, PharmD, and Pamela S. Moore, PharmD, BCGP, discuss the nuanced use of anticholinergic agents for managing terminal secretions at end of life, highlighting practical considerations, timing, safety concerns such as delirium, and the limited yet evolving evidence supporting their role in palliative care.
Breaking with the status quo in end-of-life care through de-implementation
05/03/25 at 03:20 AMBreaking with the status quo in end-of-life care through de-implementation Journal of Internal Medicine; by Chetna Malhotra and Ellie Bostwick Andres; 4/17/25... In the realm of serious illness, many patients undergo interventions that may marginally prolong life but often sacrifice quality of life and entail significant costs. These interventions, categorized as ‘low-value care’, often involve complex procedures, frequent hospitalizations and intense medical management, leading to considerable discomfort, reduced functional ability and overall decreased well-being and calling into question the efficiency and effectiveness of current end-of-life (EOL) care practices. ... How to conduct de-implementation in EOL contexts:
Breaking barriers: Ketamine's role in hospice medicine with Dr. Rohini Kanniganti
05/02/25 at 03:00 AMBreaking barriers: Ketamine's role in hospice medicine with Dr. Rohini Kanniganti Teleios Collaborative Network (TCN); podcast by Chris Comeaux with Dr. Rohini Kanniganti; 4/30/25 Ketamine – a medicine long used as an anesthetic – is finding a powerful new purpose in Hospice and Palliative Care settings. Dr. Rohini Kanagante, a physician with expertise spanning both Hospice Care and Integrative Psychiatry, unveils the remarkable potential of this medication in our latest episode of TCNtalks. [TCN is a sponsor of our newsletter.]
Part D Plans cover a larger share of Medicare Beneficiaries in rural counties
05/01/25 at 03:10 AMPart D Plans cover a larger share of Medicare Beneficiaries in rural counties Managed Healthcare Executive; by Denise Myshko; 4/25/25 Medicare beneficiaries living in more rural counties are enrolled in traditional Medicare and rely on stand-alone prescription drug plans (PDPs), according to recent analysis from KFF.In fact, in 27 states, at least half of Medicare Part D enrollees living in the most rural areas are enrolled in stand-alone prescription drug plans. This includes 8 states with 75% or more of Part D enrollees in the most rural areas in prescription drug plans (Nevada, Alaska, Massachusetts, California, Kansas, Wyoming, Nebraska, and South Dakota). Nationwide, 58% of beneficiaries living in rural areas are enrolled in stand-alone prescription drug plans in 2025. The remainder (42%) are enrolled in Medicare Advantage drug plans (MA-PDs).
Dr. Drabek's "The Comfortologist" hits #1 bestseller, revolutionizing pain management & end-of-life care approaches
05/01/25 at 03:00 AMDr. Drabek's "The Comfortologist" hits #1 bestseller, revolutionizing pain management & end-of-life care approaches Classic 96.7 FM BWZ, Yukon, OK; Press Release; 4/28/25 Dr. Steven Drabek's groundbreaking memoir, "The Comfortologist: A Physician's Empathetic Perspective on Compassion, Caring, and Pain Relief," has achieved #1 bestseller status, resonating deeply with healthcare professionals, chronic pain patients, and families navigating end-of-life care decisions. Drawing from his four-decade career and personal journey as a cancer survivor and chronic pain patient, Dr. Drabek offers readers a unique dual perspective that has earned him recognition as a "comfortologist" a term he coined to describe his approach to medicine that prioritizes patient comfort and dignity. "My experience as both physician and patient taught me that modern medicine often misses what matters most," says Dr. Drabek. "Technical expertise means little without empathy. We must treat the whole person, not just the symptoms."
CMS releases HOPE Guidance Manual (V. 1.01) and Tables
04/25/25 at 03:00 AMCMS releases HOPE Guidance Manual (V. 1.01) and TablesCenters for Medicare and Medicaid Services (CMS); by CMS; 4/22/25On April 22, 2025, CMS released the HOPE Guidance Manual (V. 1.01) and connected tables. Providers can use v1.01 for HOPE planning, as this is considered final before HOPE implementation. Also note that earlier this month, the final HOPE data specs have also been released, helping software developers to finalize their HOPE software for testing in the coming months.
Walgreens will pay up to $350M in settlement with DOJ to resolve opioid prescription lawsuit
04/24/25 at 03:00 AMWalgreens will pay up to $350M in settlement with DOJ to resolve opioid prescription lawsuit Fierce Healthcare; by Heather Landi; 4/21/25 Walgreens has agreed to pay $300 million to settle allegations from federal prosecutors that it illegally filled millions of invalid prescriptions for opioids and other controlled substances, the Department of Justice (DOJ) announced Monday. The DOJ also alleges that the retail pharmacy chain sought payment for many of those "invalid" prescriptions by Medicare and other federal healthcare programs in violation of the False Claims Act. The settlement amount is based on Walgreens’s ability to pay, the DOJ said, but Walgreens will owe the U.S. an additional $50 million if the company is sold, merged or transferred prior to fiscal year 2032.
HMN 2025: What are the obstacles to opiod accessibility for severely ailing sufferers
04/23/25 at 02:15 AMHMN 2025: What are the obstacles to opiod accessibility for severely ailing sufferers Health Medicine Network; by The Mount Sinai Hospital; 4/22/25 In a research published in NEJM Catalyst, researchers on the Icahn School of Medicine at Mount Sinai describe how measures to curb opioid overdoses within the normal inhabitants have compromised a crucial cornerstone of palliative care. ... “The opioid disaster of overdose deaths stays omnipresent; nonetheless, a brand new menace has emerged amongst susceptible populations who want these medicines as first-line remedy for his or her ache, which will be extreme,” says lead writer Rebecca Rodin, MD, Assistant Professor of Geriatrics and Palliative Medicine, Icahn Mount School of Medicine at Mount Sinai, who makes a speciality of palliative drugs. “We hope our findings will lay the muse for deeper dialog to revive stability between opioid extra and entry.”
Using technology to improve matching drug details in hospice care
04/21/25 at 03:00 AMUsing technology to improve matching drug details in hospice care Patient Safety & Quality Healthcare (PSQH); by Matt Phillion; 4/17/25 For Wise Hospice Options, prescribers had been spending an average of 15 seconds matching each flagged drug and 20 seconds per drug entering missing sig, or label, details. Recently, they incorporated clinical-grade AI from DrFirst into automating this process, enabling those same providers to spend two to three seconds per drug, with fewer medications flagged for manual review by pill icons. ... The AI implementation allowed Wise to standardize data from different systems into a workflow that allows clinicians to see complete information before ordering prescriptions, helping avoid delays and reduce errors. Clinicians continue to review medication information for accuracy and adjust based on discussions with the patient but require fewer clicks and keystrokes so they can make faster, more informed decisions. ... Why the impact on hospice is key: The first thing to consider, Faubion explains, is that when it comes to hospice patients, they are going to be on a lot of medications. ...
Florida lawmakers unanimously approve bill to make medical marijuana cards free for military veterans
04/17/25 at 03:00 AMFlorida lawmakers unanimously approve bill to make medical marijuana cards free for military veterans Marijuana Moments; by Ben Adlin; 4/15/25 A Florida House panel on Tuesday unanimously approved a bill that would exempt military veterans from state registration fees for medical marijuana cards, allowing them to obtain the certifications for free. ... If HB 555 becomes law, the changes would take effect July 1.
More than just meds: What a palliative care pharmacist learned from the bedside
04/17/25 at 03:00 AMMore than just meds: What a palliative care pharmacist learned from the bedside Pharmacy Times; by Trinh Bui, PharmD, Yale New Haven Health; April 2025 Issue A palliative care pharmacist highlights a spectrum of clinical opportunities for patients, caregivers, and clinicians when rounding at the bedside. ... I hold a unique clinical position. In 2018, the National Palliative Care Registry reported that less than 10% of national palliative care (PC) programs have a dedicated pharmacist. I am a member of the PC consultation service at a cancer hospital affiliated with a large tertiary academic medical center in New Haven, Connecticut. Routinely, we are consulted for at least 40 patients a day, with more than 2000 consults in 2024. ... A benefit of having a clinical pharmacist on the interdisciplinary team includes the ability to provide off-label medication to optimize complex medication regimens while honoring patients’ psychosocial, cultural, and spiritual needs. ...
Medicare and Medicaid officials finalize rule to clarify that medical marijuana isn’t covered by federal health programs
04/10/25 at 03:00 AMMedicare and Medicaid officials finalize rule to clarify that medical marijuana isn’t covered by federal health programsMarijuana Moment; by Kyle Jaeger; 4/8/25 The federal Centers for Medicare & Medicaid Services (CMS) has finalized a rule to clarify that marijuana products are not eligible for coverage under certain health plans for chronically ill patients because “they are illegal substances under Federal law.” In a notice set to be published in the Federal Register next week, CMS said that a series of policy and technical changes for its Medicare Advantage (MA) program and other services, including rulemaking related to cannabis products, will now take effect on June 3.[Continue reading ...]