Inpatient use of valproic acid in agitated delirium by palliative medicine

Inpatient use of valproic acid in agitated delirium by palliative medicine
American Journal of Hospice and Palliative Medicine; by Sarah Jacobs, Leah Herbst, Carlos Fernandez, Zankhana Y. Mehta, Amanda Young, Mellar P. Davis; 2/25
Valproic acid (VPA), an anti-epileptic medication available in intravenous and parenteral forms, has recently been used to treat agitation associated with delirium. VPA as an adjunct in treating delirium has been reported to be opioid, antipsychotic and benzodiazepine sparing. ... this study did show that 50% of patients did not require benzodiazepines or antipsychotics at all, and that VPA might have a role in sparing the use of medications such as antipsychotics and benzodiazepines which have poor evidence in the management of agitation in delirium.