[India] Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic pain

[India] Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic pain
Inflammopharmacology; Ardra Das, Preetha Balakrishnan; 12/24
Palmitoylethanolamide (PEA) is emerging as a promising therapeutic agent for neuropathic and other pain-related conditions. PEA's interaction with endocannabinoid receptors decreases the inflammatory cytokine and chemokine production and thereby a descending pain sensation. Experimental evidence shows that PEA not only reduces pain and inflammation but also lowers the need for higher dosages of other drugs hence minimizing the risk of drug toxicity. The bioavailability of PEA has been enhanced by recent technological developments, which emphasize continuous research efforts to maximize PEA's therapeutic potential in pain treatment and associated medical sectors.