Literature Review

EV0034 Palliative pain relief: A case study of high-frequency spinal cord stimulation in an end-of-life cancer patientNeuromodulation: Technology at the Neural Interface; P. Majedi, Dominic Bailey; 1/26A significant proportion of patients with cancer will experience cancer-related pain at some point during their illness. The treatment approach for cancer-related pain is often multifaceted and may necessitate the use of advanced interventional methods, including spinal cord stimulation (SCS). Recent studies have demonstrated the utility and efficacy of SCS techniques in the treatment of cancer-related pain and chemotherapy induced neuropathy. Here, we present a case report on a patient receiving high frequency SCS at 10 kHz for end-stage cancer-related pain.

[Austria] Hospice nurses' views about the necessity for palliative sedation in existential sufferingPain Management Nursing; Dana Hagmann, Susanne Fleckinger, Piret Paal; 1/26Disagreements between nurses and doctors regarding the assessment and management of existential suffering in terminally ill patients represent a critical challenge in palliative care, particularly in the context of inpatient adult hospices. The study highlights the limited involvement of nurses in decision-making processes regarding palliative sedation despite their critical insights into patients' existential suffering. The findings emphasize the need for interdisciplinary collaboration and the integration of nurses' perspectives to achieve more holistic and ethically sound care in inpatient hospices.

Personalized palliative care shows signs of improving quality of life for children with advanced cancer American Association for the Advancement of Science (AAAS), EurekAlert!; by Mass General Brigham; 2/4/26How to reduce suffering in children with advanced cancer remains an ongoing but urgent question. A Mass General Brigham-led study examined whether systematically surveying children with advanced cancer and their parents about their symptoms and quality of life, providing feedback to children, families, and clinicians—and acting on that information by implementing personalized palliative care—could improve patients’ experiences. Their findings, published in the Journal of Clinical Oncology, suggest that integrating feedback along with response by specialized pediatric palliative care (SPPC) has the potential to improve children’s quality of life.

“This is what loneliness looks like”: A description of a high-risk population of palliative and oncology patients American Journal of Hospice and Palliative Medicine; by Tamia Ross, MSPH, Ruwanthi Ekanayake, BA, Lucy Rabinowitz Bailey, MPH, Kain Kim, MD, and Emily Pinto Taylor, MD; 1/9/26 Background: Loneliness exacerbates symptom burden and reduces quality of life in serious illness. Social prescribing–linking patients to non-clinical community activities–offers a novel approach to address loneliness in palliative care. Results: Most patients were older, non-Hispanic Black women experiencing financial strain, food insecurity, and transportation barriers. Anxiety exceeded depression severity; mood disorders, loneliness, and social isolation were leading referral reasons.

How to responsibly use AI in palliative care and hematologic malignancies CancerNetwork; podcast by Ram Prakash Thirugnanasambandam, MBBS; 2/2/26 In a conversation with CancerNetwork®, Ram Prakash Thirugnanasambandam, MBBS, discussed the evolving roles that artificial intelligence (AI)–based tools may play in palliative care and the management of different hematologic malignancies. ... According to Thirugnanasambandam, implementing AI into one’s workflow may help accurately predict disease subtypes and burdens among patients with leukemia, lymphoma, or multiple myeloma. ... Thirugnanasambandam also discussed some of the ethical considerations surrounding the growth of AI-based tools, highlighting information privacy concerns and potentially biased datasets as notable issues with these platforms. Although AI may assist with decision-making, Thirugnanasambandam stated that it ultimately cannot replace a human’s nuanced clinical judgment and empathy.

Drivers of disease-specific end-of-life disparities Hospice News; by Holly Vossel; 1/30/26 ... Racial and ethnic disparities persist among underserved patient populations with dementia, who have a stronger likelihood of dying without awareness or access to hospice, recent research has found. Clinicians may play a vital role in moving the needle forward. Nearly 260, 000 Black, Hispanic and white Medicare decedents with dementia-related conditions were recently examined in a new study, which was published in the Journal of the American Medical Association (JAMA) Health Forum.  Editor's Note: We posted this study in our Saturday Research newsletter, 12/27/25, End-of-life care for older adults with dementia by race and ethnicity and physicians’ role. This article gives more practical descriptions and applications for its results.

Evaluating palliative care needs in patients with advanced non-malignant chronic conditions: An umbrella review of needs assessment tools Healthcare; by Chrysovalantis Karagkounis, Stephen Connor, Danai Papadatou, Thalia Bellali; 12/24/25 Patients with advanced non-malignant chronic conditions experience illness burdens and palliative care needs comparable to those of oncology patients, yet palliative care is often introduced late. Identifying individuals with potential palliative care needs is complex, and although multiple tools exist, the most appropriate approach for assessing needs in this population remains unclear. This umbrella review aimed to identify and evaluate tools used to systematically assess palliative care in adults with advanced non-malignant chronic conditions, with a specific focus on their content, structure, and psychometric properties.

[Netherlands] Pediatric advance care planning: a mixed-methods evaluation of documentation and sharing in current practice BMC Palliative Care; by Sophie Tooten, Rosella P.M.G. Hermens, Manel Verhoeven, Ellen M. Vierhoven, Fatima Boulakhrif, Jana M. Reintjes, Michel A.A.P. Willemsen, Judith L. Aris-Meijer, Jurrianne C. Fahner, Marijanne Engel, Marijke C. Kars, Inge M.L. Ahout & Esther Deuning-Smit; 1/29/26 Pediatric advance care planning (pACP) aims to align future care and treatment of children with life-limiting conditions (LLCs) with children’s and their families’ values, goals and preferences. Documenting and sharing pACP elements with healthcare professionals (HCPs) is essential for goal-concordant care. This study evaluates how pACP elements are documented in electronic health records of children with LLCs and shared with other HCPs.

Integrating psychiatric and hospice services: Legal and clinical considerations for involuntary commitment in multimorbid end-of-life care American Journal of Hospice and Palliative Medicine; by Ilana Marmershteyn, BS, Darian Peters, BS, Victor Milev, BS, Mario Jacomino, MD, MPH, and George Luck, MD, FAAHPM; 1/28/26  Multimorbid patients at the end-of-life face complex medical, psychosocial, and psychiatric challenges. Hospice care aims to address physical, emotional, and spiritual needs; however, psychiatric comorbidities, particularly acute crises, remain under-recognized and inconsistently managed. The intersection of psychiatric intervention, hospice care, and legal frameworks such as involuntary commitment presents significant clinical and ethical challenges.

How do I tell my patient they’re dying? Medscape; by Lisa Mulcahy; 1/27/26 Ruth Parry, PhD, still remembers a conversation she mishandled as a junior National Health Service stroke rehabilitation physiotherapist many years ago. ... Since then, Parry has analyzed nearly 100 video consultations between practitioners and patients with poor prognoses in stroke and head injury and with terminal diagnoses. Her research explores a critical clinical dilemma: How do doctors navigate the delicate balance of providing fair, accurate information about dire prognoses while respecting a patient’s feelings and personal choices?

The most important thing you need to know about end of life planning Forbes; by Peter Ubel; 1/22/26 ... Many experts say I should document my preferences clearly and unambiguously in my medical records so that, in the case of mental incapacity, my doctors can look at what I say and honor those preferences. According to the AARP, leaving ahead detailed instructions about your end-of-life preferences means “that you remain the captain of your own ship.” ... I respect these experts. And I do not begrudge anyone who has filled out such a document. But I worry that this approach won’t work and could even backfire. That is why I prefer a different approach, which I will describe shortly. But first, I need to explain why these kind of detailed advanced directives could backfire. ...

Improving timeliness of palliative care referrals within the ICU: A quality improvement project Dimensions of Critical Care Nursing (DCCN); by Stephanie Fiore, Simone O'Donovan, Kerry A Milner; 1/23/26 ... Using the Model for Improvement, this quality improvement project was conducted over 7 months, including a 4-month baseline phase and a 3-month implementation phase. ICU nurses used a PC screening tool to evaluate patients within 48 hours of admission. The project aimed to increase PC screenings to 75% and ensure PC referrals within 48 hours. ...  The implementation phase saw a significant increase in PC screenings, with compliance reaching 90.9% after process adjustments.