Literature Review

IU Health gets $20M gift for clinical innovation institute  Becker's Hospital Review; by Madeline Ashley; 5/20/25 Indianapolis-based Indiana University Health has received a $20 million donation from Sarah and John Lechleiter and Deborah and Randall Tobias to create the Tobias-Lechleiter Institute for Clinical Innovation. IU Health will match the donation, bringing the investment in the institute to $40 million, according to a May 20 news release shared with Becker’s. ... The institute plans to recruit 75,000 residents yearly in advanced medical studies; enroll 300,000 patients in the Indiana Biobank initiative over five years to aid research into genomic risk factors pertaining to Indiana’s population; attract and retain top fellows, students and faculty; enhance research resources; and increase the impact and pace of statewide medical research.

‘Wake-up call’: Aggressive cancer care common at end of life, supportive care lackingHealio; by Josh Friedman; 5/22/25Nearly half of people with advanced cancer receive aggressive care at the end of life, a rate little changed from a decade ago. At the same time, use of palliative or supportive care remains rare, despite increasing evidence that they are a key component of high-quality, patient-centered care. ... Meanwhile, two other studies showed oncologists’ individual practice patterns and institutional resources can play a significant role in determining which patients receive systemic therapy or early palliative care at the end of life.

Yes, you can die from a broken heartMedscape; by F. Perry Wilson, MD, MSCE; 5/14/25 A patient comes crashing into the emergency room with severe chest pain. The EKG looks like this: A patient comes crashing into the emergency room with severe chest pain. The EKG looks like this: [graphic]. As a doctor, if you see this, you’re calling the cardiac cath lab. This is an ST-elevation myocardial infarction — the big one — indicative of a blood clot blocking blood flow to a large section of the heart. The sooner you get that blood clot out, the better chance the patient has to survive. So the patient is rushed to the cath lab, and they find… nothing. Clear coronaries. No blood clot. Further questioning reveals that the patient, an older woman, lost her husband recently. This is stress-induced cardiomyopathy, medically known as Takotsubo cardiomyopathy (TC). It’s the pathophysiologic manifestation of a broken heart. First described in 1991, Takotsubo syndrome occurs in the setting of deep psychological, emotional, or physical stress.

New standards could transform palliative care for dementia patients McKnights Long-Term Care News; by Donna Shryer; 5/15/25 An Invited Commentary published Wednesday [5/14/ in JAMA Network Open highlights vital new consensus on when to refer dementia patients to specialist palliative care. The commentary, authored by Laura J. Morrison, MD, from Yale University School of Medicine, analyzes the Delphi survey study, which established the first international agreement on palliative care referral criteria for dementia patients.The Delphi survey study, led by Yuchieh K. Chang, DO, and colleagues, brought together 63 experts from five continents who identified 15 major criteria for specialist palliative care referral, grouped into five categories: dementia type, symptom distress, psychosocial factors, comorbidities and hospital use. Each major criterion was considered sufficient on its own to warrant referral, even for patients expected to live more than two years. Additionally, the study outlined 42 minor criteria, which could be used in combination to justify a referral decision.

In the wake of HICPAC: How APIC is leading the fight to preserve national infection prevention standards Infection Control Today, Branbury, NJ; by Tori Whitacre Martonicz; 5/13/25 The Trump administration has disbanded a federal advisory committee that guided efforts to prevent the spread of infections in health care facilities. The Healthcare Infection Control Practices Advisory Committee (HICPAC) established national standards for hand hygiene, mask-wearing, and isolating patients with infectious diseases that most US hospitals adhere to.Infection Control Today® (ICT®) spoke with Connie Steed, MSN, RN, CIC, FAPIC, an infection prevention consultant and former president of the Association for Professionals in Infection Control and Epidemiology (APIC), about HICPAC's disbanding and its implications for national standards in infection control.

New study uncovers significant variations in life expectancy across U.S. states Bioengineer.org - Health; by Bioengineer; 5/7/25 "A Century of Unequal Longevity: How Geography and Policy Sculpt Life Expectancy in the United States"In an extensive new investigation led by the Yale School of Public Health (YSPH), researchers have unveiled profound disparities in life expectancy trends throughout the United States over the last hundred years. This groundbreaking study reveals how the interplay between public health policies, social environments, and regional factors critically shapes the longevity of populations across states and the nation’s capital, Washington, D.C. ... The findings are striking: while states in the Northeast and West Coast, alongside the District of Columbia, achieved remarkable gains in life expectancy over the twentieth century, several Southern states remained largely stagnant. Specifically, females born in some parts of the South experienced life expectancy increases of less than three years between 1900 and 2000.

To the brink and back: How near-death experiences can change how people work The Conversation; by Adauri.AI; 5/5/25 What happens when someone comes close to death and then returns to everyday life, including work? For some, the experience can be transformative. ... Although near-death experiences (NDEs) have been studied since the 1970s, we know relatively little about how they affect people after the event. Research suggests people who have near-death experiences may feel increased empathy, spiritual growth, a sense of purpose and even change how they approach their jobs. Our recent study explored how near-death experiences impact people’s return to work. We interviewed 14 working adults who had a near-death experience as a result of medical crises such as a heart attack or accidents such as a car crash. What we found challenges conventional ideas about success, motivation and workplace culture.

University of Minnesota uses VR to study Alzheimer's, death Government Technology (GT) - Center for Digital Education; by Richard Chin; 5/2/25 At the University of Minnesota, medical school students have been using a virtual reality experience to understand the perspective of a woman dealing with the advanced stages of Alzheimer’s. ... When the University of Minnesota offered to let me experience what it’s like to die, naturally I said yes. Aren’t we all morbidly curious about the undiscovered country, as Hamlet put it, from which no traveler returns? Except this time, happily, I would get to return because it would be a virtual death, an experience in a VR studio that’s part of the university’s Health Sciences Library system. The dying experience is part of a series of VR simulations developed by a nine-year-old California-based company called Embodied Labs. They’ve created immersive, first-person experiences of what it’s like to have dementia, Alzheimer’s or Parkinson disease, vision or hearing loss, to be socially isolated or to experience aging as a LGBTQ person. And what it’s like to die.

Research study participation: NIH MAiD study recruitmentPersonal communication; by Stacy Fischer, Dan Matlock; 4/22/25We are Dr. Stacy Fischer and Dr. Dan Matlock, physicians at the University of Colorado Anschutz Medical Campus and co-principal investigators on a National Institutes of Health-funded study to understand the experiences of patients seriously considering medical aid in dying and their caregivers. Our multidisciplinary team includes geriatricians, bioethicists, and both quantitative and qualitative experts... Our goal is to recruit 300 patients and caregivers nationwide, and we would deeply appreciate your continued support in helping us connect with individuals who are seriously considering MAiD and their caregivers (e.g., those who have scheduled or completed their first MAiD consultation).

Assisted dying and the slippery slope argument—no empirical evidence

Research study participation: Practice Analysis StudyHMDCB email; 4/24/25The Hospice Medical Director Certification Board (HMDCB) is conducting a Practice Analysis Survey and we are seeking your help to gather physician feedback. If you haven't already, we encourage you to share this email with your hospice physicians/medical director and encourage them to participate.

HHS cuts funding for NIH-based Women's Health Initiative threatening decades-long study The American Journal of Managed Care (AJMC); by Giuliana Grossi; 4/23/25 HHS is defunding the regional research centers that have been conducting a long-term national health study focusing on preventive strategies for women's health since 1991, the largest study investigating women’s health in US history. The Women’s Health Initiative (WHI) regional centers will close by September 2025, at the end of the fiscal year, according to an announcement from the NIH-based initiative. Investigators at the WHI were informed by HHS earlier this week, although formal written notice from HHS is still pending.