Literature Review

BMI at diagnosis and pre-diagnosis weight loss as predictors of stage and survival in hepatocellular carcinomaJournal of Clinical Oncology; by Tatiana Ermi, Daniel Kiser, Gai Elhanan, Harry Menon, Joseph Grzymski, Katharine Thomas; 1/26Body mass index (BMI) is a recognized risk factor for hepatocellular carcinoma (HCC), but its relationship to stage at diagnosis, survival, and the “obesity paradox” remains uncertain. Obesity at the time of HCC diagnosis, but not years earlier, was associated with earlier stage and improved survival, while pre-diagnosis weight loss predicted worse outcomes, particularly within the first months after diagnosis. These findings may contribute to the “obesity paradox” discussion in cancer outcomes, in which obesity appears to increase cancer risk overall but paradoxically appears to offer survival protection after diagnosis. Additionally, further studies are needed to investigate this relationship. If validated, consideration should be made as to whether BMI at diagnosis could play a role in both prognostic discussions and risk stratification in HCC.

Palliative care physician explains living and dying with ALS Forbes; by Adaira Landry, MD, MEd; 2/26/26 Actor Eric Dane’s recent death from amyotrophic lateral sclerosis (ALS) has drawn national attention. ... Beyond the headlines lies a deeper and more urgent discussion: what life—and death—look like for patients living with ALS. To better understand both the clinical and scientific landscape, I spoke with Dr. Maria “Marissa” Mapa, an internal medicine and palliative care physician who treats patients with ALS, and Dr. Melanie Leitner, chief scientific officer of the ALS Investment Fund, about current and future research directions.

The burden of the eldest daughter MedPage Today's KevinMD.com; podcast by Jessie Mahone, MD; 10/15/25 Were you the one who always held it together? The responsible one? The one who made sure everyone else was OK, sometimes at the cost of your own well-being? For most eldest daughters, this role is inevitable. We don’t choose it. We are handed it, early and often, because we are so “capable.” We accept this role and excel at it. That’s what most eldest daughters do with whatever is handed to us. Recently, my podcast cohost, another female physician, and I realized we had so many shared “eldest daughter” experiences. 

How compliance technology can improve day-to-day operations BusinessABC; by Peyman Khosravani; 2/25/26 ... Compliance technology, compliance software, or regtech, is the use of software and technology to help companies adhere to regulatory, legal, and internal requirements, and the automation of monitoring, reporting, and auditing of compliance. ...

Awards and Recognitions: February 2026

Friends of Hospice starts life longings bucket list program WSYR-TV, Syracuse, NY; by Iris St. Meran; 2/26/26 Losing a friend or loved one is never easy. That’s why organizations like Friends of Hospice in Oswego County are important. They provide non-medical support and have a new initiative to help those facing a life limiting diagnosis fulfill bucket list requests. Elena Twiss, the executive director shared more about the Life Longings program. It is designed to support individuals facing a life-limiting diagnosis by fulfilling “bucket list” requests, making comfort improvements, or helping with milestone celebrations. To learn more about life longings and the other resources friends of hospice provides visit FriendsOfHospice.org.

Alliance 2025 Facts and Figures Report now available The National Alliance for Care at Home; Alexandria, VA and Washington, DC; Press Release; 3/3/26 The National Alliance for Care at Home (the Alliance) published the 2025 edition of Facts and Figures, an annual report on key data points related to the delivery of hospice care, including information on patient characteristics, location and level of care, Medicare hospice spending, hospice provider characteristics, and quality of care. Facts and Figures – the leading resource for hospice providers and others interested in understanding the work of the community – has been published annually for over two decades. The findings in this report reflect patients who received care in 2024, provided by hospices certified by the Centers for Medicare & Medicaid Services (CMS) and reimbursed under the Medicare Hospice Benefit. ... The full 2025 Facts and Figures report is available for Alliance members online. The Executive Summary is available to the public.  Editor's Note: Pair this national data with the The Alliance and the Research Institute for Home Care release 2025 Hospice Chartbook that we posted on 2/20/26. The RIHC Hospice Chartbook mainly provides state views with some national treands, whereas this Facts and Figures report is mainly a national view with time trends.

Executive Summary: Society of Critical Care Medicine Clinical Practice Guidelines on Adult End-of-Life Care in the ICUCritical Care Medicine; by Mary Faith Marshall, F Daniel Davis, Patricia A Fogelman, Simon Oczkowski, Julie C Reid, Daniel Arellano, Rebecca A Aslakson, Joshua Campbell, Katherine Courtright, Katarine Egressy, Elizabeth Epstein, Ebonye Green, May Hua, Preeti R John, Erin K Kross, Niels D Martin, Bethany A Melo, Susanne Muehlschlegel, Silvia Perez-Protto, Ben Roberts, Daniel Shalev, Jennifer Wescoe Singley, Shawna L Strickland, Karen A Korzick; 12/25[Recommendations include:]

Use of nebulized tranexamic acid (TA) in combination with nebulized recombinant coagulation factor VIIa to treat hemoptysis in pediatric patients with cancer at end-of-life (EOL)Journal of Pain and Symptom Management; by Santosh Yatam Ganesh, Nelda Itzep, Eduardo Bruera; 2/26Hemoptysis is a distressing symptom for both patients and families at end of life (EOL). In the acute care setting, this can be managed surgically or medically. However, research regarding interventions, such as nebulized tranexamic acid (TA) and nebulized factor VIIa, for palliative management of hemoptysis at EOL is limited. In our case series, we found that combination of nebulized recombinant factor VIIa and nebulized TA relieved hemoptysis in both pediatric cancer patients at the end of life. This case series highlights the potential use of this combination to reduce suffering and distress secondary to hemoptysis in the palliative setting.

Values considerations in telemedicine: Pause before shiftingJournal of Pain and Symptom Management; by Meaghann S. Weaver, Kenneth A. Berkowitz; 12/25As a contingency standard of care, telemedicine use surged during the COVID-19 pandemic. The Medicare telehealth flexibilities introduced during the COVID-19 pandemic expired in September 2025. Any ongoing sustained pivot to telemedicine warrants purposeful attentiveness to ethical considerations and not just technology use as an end unto itself. Telemedicine has the potential to complement face-to-face care practices and enhance clinical interactions when its use is based on shared values. Values such as access, equity, justice, compassion, autonomy, and dignity warrant thoughtful use of telemedicine. Patients and families need to be able to trust that clinicians and health systems will place patient welfare and shared values above technical convenience. As demonstrated in this case description, upholding values fundamental to the practice of medicine in telemedicine can enhance patient connection and foster trustworthy postpandemic practices.

Dementia, taboo, and the need for a cultural reckoningJournal of Aging Studies; Kelly Marnfeldt; 3/26Dementia is one of the most feared and misunderstood conditions of our time. Even as public awareness has increased, people living with dementia continue to face exclusion, moral disregard, and systemic neglect. Decades of advocacy, education, and contact-based interventions have sought to reduce stigma. [This study] proposes that dementia becomes stigmatized not only because it is misunderstood, but because it violates cultural expectations of personhood, consistency, and intelligibility. The paper concludes by proposing culturally grounded provocations that imagine what it might look like to reframe how dementia is seen, told, and recognized, both socially and culturally.