Literature Review

Artificial intelligence and health care waste—Promise or peril?JAMA Health Forum; William H. Shrank, MD, MSHS; Suhas Gondi, MD, MBA; David J. Brailer, MD, PhD; 6/25One obvious target of AI [artificial intelligence] tools in health care is the reduction of waste. While LLM [large language model] applications to health care are still nascent—many still make errors, and more rigorous evaluations are needed—most agree that the long-term opportunity for AI in health care is tremendous. A recent study estimated that widespread adoption of AI could lead to savings of 5% to 10% of total US health care spending. Realizing even a fraction of this potential would increase the affordability of care for people in the US and free substantial societal resources to make other valuable investments. But getting there will require deliberate choices from leaders and policymakers and careful attention to risks that could set back progress.

Zuranolone in palliative care: Promise and practicality for the rapid treatment of depressionThe American Journal of Hospice & Palliative Care; Eric Prommer; 6/25Zuranolone is an orally available antidepressant classified as a neuroactive steroid. Neuroactive steroids act as positive allosteric modulators for both synaptic and extrasynaptic GABA, making them distinct from currently available drugs targeting major depression and insomnia. By modulating GABA binding sites, neuroactive steroids enhance the function of GABA, which is depressed in major depression. The drug has a rapid onset of action, which differs from currently available antidepressants that are used in palliative care. [This] ... paper will review the pharmacology, pharmacodynamics, safety profile, and clinical studies showing its effectiveness in major depression and how it can potentially be helpful in the palliative care population.

Unanswered questions on private equity in gastroenterologyJAMA Network; by Jane M. Zhu; 6/25A growing literature on private equity (PE) acquisitions of physician practices has found associated increases in health care prices and utilization, but evidence specific to gastroenterology remains relatively new despite the specialty being a popular target for PE. More than 1 in 8 gastroenterology practices are now owned by PE, with practice fragmentation, lucrative procedural reimbursements, and an aging population factoring into continuing investor interest... Taken together with observations of increased utilization, there may be 2 interpretations of the data presented by Arnold and colleagues. One interpretation of the findings may be that PE acquisition may focus on reducing inefficiencies, improving access by expanding practice capacity, and increasing throughput. Another interpretation may be that PE acquisition is focused on the strategic exploitation of market and pricing power. The latter may have less of an impact on clinical measures like quality of care, but potentially, both strategies could be at play.Publisher's note: Similar questions being asked across hospice, gastroenterology, physician practices, and other areas of healthcare.

Physicians' preferences for their own end of life: A comparison across North America, Europe, and AustraliaJournal of Medical Ethics; Sarah Mroz, Sigrid Dierickx, Kenneth Chambaere, Freddy Mortier, Ludovica De Panfilis, James Downar, Julie Lapenskie, Koby Anderson, Anna Skold, Courtney Campbell, Toby C Campbell, Rachel Feeney, Lindy Willmott, Ben P White, Luc Deliens; 6/25Setting: Eight jurisdictions: Belgium, Italy, Canada, USA (Oregon, Wisconsin, and Georgia), Australia (Victoria and Queensland). Participants: Three physician types: general practitioners, palliative care physicians, and other medical specialists. Conclusion: Physicians largely prefer to intensify alleviation of symptoms at the end of life and avoid life-sustaining techniques. In a scenario of advanced cancer or Alzheimer's disease, over half of physicians prefer assisted dying. Considerable preference variation exists across jurisdictions, and preferences for assisted dying seem to be impacted by the legalisation of assisted dying within jurisdictions.

[Korea] Alzheimer Disease in Breast Cancer survivorsJAMA Network; by Su-Min Jeong, Wonyoung Jung, Hyeonjin Cho, Hea Lim Choi, Keun Hye Jeon, Ki-Woong Nam, Yun-Gyoo Lee, Bongseong Kim, Kyungdo Han, Dong Wook Shin; 6/20Is breast cancer survivorship associated with the risk of Alzheimer dementia (AD), and how are cancer treatments associated with this risk? Breast cancer survivors may have a slightly lower risk of AD compared with cancer-free individuals, potentially influenced by cancer treatments, underscoring the need for further research on long-term neurocognitive outcomes in this population.

Serious illness conversations in the Emergency Department for older adults with advanced illnesses - A randomized clinical trialJAMA Network; by Kei Ouchi, Susan D. Block, Dorene M. Rentz, Donna L. Berry, Hannah Oelschlager, Youkie Shiozawa, Sarah Rossmassler, Amanda L. Berger, Mohammad A. Hasdianda, Wei Wang, Edward Boyer, Rebecca L. Sudore, James A. Tulsky, Mara A. Schonberg; 6/25Does an emergency department (ED)–based intervention to discuss serious illness care goals improve advance care planning outcomes for older adults with advanced illnesses? In this randomized clinical trial including 141 patients in the ED, a nurse-led intervention to discuss serious illness care goals did not significantly improve patient-reported engagement in advance care planning but did increase subsequent clinician-documented serious illness conversations in the medical records. These findings suggest that ED visits may serve as a critical access point for serious illness conversations in clinically stable older adults with advanced illnesses.

Re-examining early in early palliative care: Precedent, reality, and future research prioritiesJCO Oncology Practice; by Laura A. Petrillo, Julia L. Agne; 6/25Nearly 700,000 people in the United States are living with metastatic solid tumor malignancies in 2025, a number that continues to grow because of advances in survival-extending therapy. Even with therapeutic advances, however, metastatic cancer continues to negatively affect patients' quality of life because of bothersome symptoms and psychological, social, and spiritual distress. Palliative care is specialized medical care focused on alleviating suffering for individuals with serious illness, including those with advanced cancer. On the basis of on substantial evidence demonstrating its efficacy in improving quality of life, ASCO and other organizations now recommend the early integration of palliative care with oncology care for all individuals living with advanced cancer. [Also see accompanying article: Early Integration of Outpatient Palliative Care Among Adults With Advanced Cancer in a Safety-Net Health System: A Patterns of Care Analysis; by Lisa DiMartino, Vincent Merrill, Celette Sugg Skinner, Timothy P. Hogan, Navid Sadeghi, Alva Roche-Green, Winnie Wang, Arthur S. Hong]

Aroostook House of Comfort’s 12th Annual Golf Classic raises $90,000[ME] The County; 6/20/25The Aroostook Hospice Foundation proudly hosted its 12th Annual Golf Classic on Saturday, June 14 at the Presque Isle Country Club, raising approximately $90,000 in support of the Aroostook House of Comfort. This achievement was made possible through the generous support of 166 sponsors, 42 teams, 42 raffle and prize donors, 14 in kind donors and 32 volunteers who came together to make the day a success.

Community Hospice & Palliative Care launches "Mail Call" program to honor Veteran patientsJaxChamber; 6/24/25Community Hospice & Palliative Care (Jacksonville, FL) is proud to announce the launch of its new "Mail Call" program, designed to honor and appreciate our veteran patients in a deeply personal way. This initiative expands upon our existing veteran recognition ceremonies, enriching the end-of-life care experience for those who have served our country. The "Mail Call" program invites volunteers, students, and community members to write heartfelt letters to our veteran patients. These letters, reminiscent of the cherished mail from home during their service years, offer messages of gratitude, encouragement, and personal reflections. Participants can choose to include their name or school, allowing students to share their appreciation directly with our veterans.

Hospice care not meant to be a last resort, offers more benefits[NH] The Laconia Daily Sun; by Anna Swanson, Pemi-Baker Hospice & Home Health; 6/24/25Hospice care is often misunderstood. Too many families see it as a last resort — something to turn to only when there’s “nothing else to do.” But at Pemi-Baker Hospice & Home Health, we see it differently. Hospice is not about giving up. It’s about choosing how to live. Hospice care is a gift — a chance to focus on what truly matters when time is short. It’s about comfort, dignity, and presence. It’s about saying yes to meaningful moments and no to unnecessary suffering.

Measuring what matters: The untapped power of resident experienceMcKnight's Long-Term Care News; by Charles de Vilmorin; 6/25/25In today’s senior living and long-term care environment, doing well financially depends on doing good — truly good. Communities that thrive are the ones that deliver on the promise of person-directed living, where residents are not passive care recipients but active participants in a life of dignity, purpose and connection. This isn’t just a moral imperative — it’s a strategic one. The industry has long recognized the importance of resident quality of life, but often fails to define or measure it with the same rigor applied to occupancy or staffing ratios. This is a missed opportunity. Resident experience remains one of the most powerful, untapped levers for operational improvement, competitive differentiation and financial growth. It’s time we treat it like the performance driver it is.Publisher's note: The balance of "mission and money" is equally true in hospice.

Social Media Watch 6/27/25

Healthcare’s broken math: 11 signs the numbers don’t add upBecker's Hospital Review; by Scott Becker, Molly Gamble; 6/25/25Healthcare has a daunting and growing supply and demand problem. We have a growing population in the United States and not enough physicians, nurses, allied healthcare providers and technicians. It is a very clear and simple math problem. We have approximately 340 million people in the United States and only about 840,000 direct patient care physicians and about 5.3 million nurses. Similarly, we face shortages across the board in other provider types and critical staff roles. [Imbalances include:]