Literature Review

Initiation of pregabalin vs gabapentin and development of heart failureJAMA Network Open; by Elizabeth E. Park, Laura L. Daniel, Alyson L. Dickson, Meghan Corriere, Puran Nepal, Kathi Hall, W. Dale Plummer, William D. Dupont, Katherine T. Murray, C. Michael Stein, Wayne A. Ray, Cecilia P. Chung; 8/25Both pregabalin and gabapentin are common nonopioid medications used to treat chronic pain, which affects up to 30% of patients. Because pregabalin has greater potency than gabapentin in binding to the α2δ subunit of the L-type calcium channel, pregabalin may be associated with an increased risk for heart failure (HF). The findings suggest that pregabalin should be prescribed with caution in older patients with noncancer chronic pain.

Differences in after-death communications: A comparative analysis of unexpected vs. expected deaths and their impact on survivors' grief and perception of deathOmega; by Tess H McCormick, Gwen Grams, Fatma A Wise, Madeline Burns, Ashna Charania, Noelle St Germain-Sehr, Chris Roe, Callum E Cooper, David Lorimer, Evelyn Elsaesser, Jennifer Kim Penberthy; 9/25This study explores changes in grief and fear of death in individuals who reported after death communications (ADC) from people who died unexpectedly or whose death was expected. We found that those bereaved by unexpected loss reported significantly higher levels of uncertainty regarding changes in their fear of death compared to those bereaved by an expected loss. However, no significant differences were found in grief between the two groups. Most participants reported a positive impact of ADC on their bereavement, regardless of the type of loss they experienced.

[India] Cancer cachexia: A meta-analysis of prevalence, outcomes, and interventionsSaudi Journal of Medicine; by Dr Sharique Ahmad, Dr Saeeda Wasim; 8/25Cancer cachexia, also known as cancer wasting, is a debilitating metabolic syndrome characterized by progressive weight loss, skeletal muscle atrophy, and systemic inflammation that cannot be fully reversed with standard nutritional support. It represents a distinct clinical entity, separate from malnutrition, due to its unique pathophysiology involving tumor-hostinteractions, cytokine-driven catabolism, and alterations in energy metabolism. This meta-analysis demonstrates that cancercachexia is highly prevalent, particularly in pancreatic and lung cancers, and strongly predicts poor survival and reduced treatment tolerance. Its high prevalence and significant impact highlight the urgent need for early recognition and systematic management in oncology practice.

[China] "Love over fear": How nostalgic songs and relationship types buffer death anxietyHealth Communication; by Weixi Zeng, Junyi Chen; 8/25From the perspective of terror management theory (TMT), this study examines the potential of music to alleviate death anxiety. Multiple interaction effects among mortality salience, nostalgia, and relationship type indicated that romantic songs - especially nostalgic romantic songs - were more effective in reducing death anxiety than parent-child relationship songs. The findings highlight the defensive function of romantic relationship songs within the TMT framework, offering new insights for clinical interventions and public mental health practices aimed at managing death anxiety.

Living with dementia: To improve lives, we need to change how we think and talk about this experience in aging societies EurekAlert! - AAAS (American Association for the Advancement of Science); peer reviewed publication by The Hastings Center; 9/24/25 To experience or even contemplate dementia raises some of the most profound questions: What does it mean to be a person? How does someone find meaning in life while facing progressive neurological deterioration? ... To improve the lives of our fellow citizens who are living with dementia or providing dementia care, all of us need to pay attention to how we imagine and talk about these interwoven and increasingly common experiences, concludes Living with Dementia: Learning from Cultural Narratives in Aging Societies, a special report published by The Hastings Center for Bioethics. This report responds to calls from health care and social service practitioners for new ways to depict and talk about dementia, a collective term for Alzheimer disease and related dementias. Editor's Note: Click here for free access to multiple articles in this crucial report, such as

[Canada] Availability of respite care almost triples a palliative care patient’s chance of dying at home EurekAlert! - AAAS; News Release by McGill University; 9/22/25 Access to respite services for family caregivers increases a palliative care patient’s probability of dying at home almost threefold, according to a McGill University-led study. Previous surveys suggest most Canadians with a serious illness would prefer to spend the end of their lives at home. ... Funded by Quebec’s health ministry as part of its action plan for equitable access to quality palliative and end-of-life care, the study set out to find which factors matter most in helping patients avoid a transfer to a hospital or palliative care centre in their final days. Respite care – professional help that allows family caregivers to take short breaks –emerged as the strongest predictor, with patients 2.7 times more likely to die at home when it was available.

The new clinician-scholars—dual training in medicine and humanities drives health research innovation JAMA; by Vinayak Jain, MD; Kayla Zamanian, MS; Lakshmi Krishnan, MD, PhD; 9/18/25 Clinicians and researchers operate in an evolving landscape that demands innovative approaches to knowledge production and dissemination. Emerging technologies like artificial intelligence are transforming health care, public trust in scientific institutions is deteriorating, and major centers of biomedical research are grappling with programmatic and funding disruptions. In response, a new paradigm of clinician-scholar must emerge—one equipped not only with scientific fluency, but also the conceptual, analytical, and structural tools of humanities and social sciences.

Beyond grief: Quantifying bereavement needs of rural family caregiversPalliative and Supportive Care; by Catherine Vanderboom, Diane Holland, Cory Ingram, Brystana G Kaufman, Allison Gustavson, Jay Mandrekar, Ann Marie Dose, Ellen Wild, Carole Stiles, Joan M Griffin; 9/25Family caregivers (FCGs) may experience numerous psychosocial and practical challenges with interpersonal relationships, mental health, and finances both before and after their care recipient (CR) dies. The specific challenges affecting rural FCGs who often have limited access to palliative care services, transitional care, and other community resources are not well understood... Bereavement support should extend beyond a focus on grief to include practical challenges experienced by FCGs. Because challenges experienced in the bereavement period often begin before a CR's death, there is benefit in continuity of FCG support provided by a known clinician from pre- to post-death. When given an option, many rural FCGs are open to bereavement support as early as a week after the death of a CR.

Suicide bereavement among Black-Americans: Evidence from the General Social SurveyOmega-Journal of Death and Dying; by William Feigelman, Julie Cerel, John McIntosh, Nina Gutin, Alice C. Edwards; 8/25Limited research attention has focused on examining the diverging adaptations of American Blacks and Whites to suicide losses. We utilized the 2016 General Social Survey, which included questions related to experiencing suicide bereavement, investigating hypotheses past studies suggested predicting Blacks face more grieving difficulties than their White counterparts. This data did not confirm any evidence of heightened grief or mental health problems among the Black respondents. Owing to the limited number of measurements of mental health assessments more research will be needed to confirm these findings.

“I know you didn’t want to stay”: Emergency Department conversations about disposition for people living with dementia The Gerontologist; Justine Seidenfeld, Matthew Tucker, Melissa Harris-Gersten, Gemmae M Fix, Nina R Sperber, Susan N Hastings; 8/25When people living with dementia present to the emergency department (ED), the disposition decision- to admit them to the hospital or discharge them home- can be difficult for providers. Major themes included 1) disposition conversations had significant variation in depth and content, 2) patient and care partner participation varied with disposition, and 3) satisfaction was driven by alignment of disposition preferences. Our study suggests that there are no consistent formats of disposition conversations for people living with dementia. Improving quality may be most needed when preferences are misaligned, and this should be identified early in the encounter.

[UK] Key themes and approaches in palliative and end-of-life care education for the general public: A systematic reviewBMC Palliative Care; by Muzeyyen Seckin, Rumandeep Tiwana, David Fry, Cara Bailey; 8/25 These [twenty] studies involved a total of 10,307 participants and identified 16 different educational programmes for the public, volunteers, and lay caregivers. The analysis revealed six main themes: foundational concepts and philosophies, communication and decision-making, planning and preparation, symptom management, end-of-life care practices, and caregiving support. This review highlights the importance of training programmes to improve community involvement in caregiving and enhance the quality of care for individuals with life-limiting conditions. Expanding access to such educational resources can empower more people to contribute confidently to end-of-life care in their communities.

Top ten tips palliative care clinicians should know about intentionally interprofessional collaboration Journal of Palliative Medicine; by Michelle M Milic, DorAnne Donesky, Naomi Tzril Saks, Rebecca Cammy, Constance Dahlin, Susan DeSanto-Madeya, Tracy Fasolino, Seiko Izumi, Amanda Kirkpatrick, Joshua R Lakin, Vickie Leff, Kashelle Lockman, Jennifer Walter, William E Rosa, Cara L Wallace; 9/9/25 This article supports individuals to practice at the top of their education, clinical training, and scope of practice while maximizing the functionality of the palliative care team as a whole. We intentionally use the term interprofessional rather than interdisciplinary to clarify that we are focused on collaboration of team members who represent multiple professions or occupations that require specialized training and meet ethical standards (e.g., nursing, chaplaincy, social work, medicine, and pharmacy) rather than interactions among specific fields of study (e.g., cardiology, nephrology, and oncology).

Developing competencies to advance health care access and quality for Latino, Hispanic, and Spanish origin populations-A consensus statementJAMA Network Open; by Débora H. Silva, John A. Davis Rodríguez, Hector Rasgado-Flores, Pilar Ortega, Deion Ellis, Fernando Sánchez Mendoza, Victor Cueto, Fabiola Quintero-Rivera, Norma Iris Poll-Hunter, Minerva Romero Arenas, Kenneth Lee Dominguez, Juan Emilio Carrillo, José E. Rodríguez, John Paul Sánchez; 8/25Question: What competencies and milestones are essential for advancing health equity for Latina, Latino, Latinx, Latine, Hispanic, and Spanish Origin (LHS+) populations? Since the 1970s, the LHS+ population has increased 6-fold and grown to be the largest ethnic or racial group in the US and accounts for approximately 20% of the US population. The LHS+ health equity competencies and milestones resulting from this study add to prior work by creating a blueprint for standardization and broader application of such educational experiences on a national level. As a tool to enhance CBME [competency-based medical education ] efforts aligned with care for LHS+ populations, the competencies may aid educators and institutions through an LHS+–informed lens in conducting gap analyses for the development of local curricula, developing teaching and assessment materials, supporting the professional development of learners and faculty, and facilitating educational scholarship.